Fig. 9

Enriched gene sets in the Hallmark collection for high- and low-risk patients. The high-risk group was associated with Hedgehog signaling, KRAS signaling, Wnt/β catenin signaling, apical junction, epithelial mesenchymal transition, and angiogenesis, whereas functional enrichment in the low-risk group was focused on energy-metabolism-related functions, including fatty acid metabolism and oxidative phosphorylation. Each uniquely colored line represents a particular gene set. The lines above the X axis indicate gene sets enriched in the high-risk group, and the lines under the X axis indicate the gene sets enriched in the low-risk group. The Y axis represents the enrichment score. The higher the absolute values of the score, the more significant the enrichment