Skip to main content

Table 3 Positive and adverse effects of RFA and SBRT treatment on different multifocal lesions1

From: Optimal application of stereotactic body radiotherapy and radiofrequency ablation treatment for different multifocal hepatocellular carcinoma lesions in patients with Barcelona Clinic Liver Cancer stage A4–B1: a pilot study

No.

Treatment intervals

(days)2

Possible adverse reaction

Possible patient benefit

leukocytes

platelets

AST

ALT

T-BIL

ALBI stage

Tumor response3

Recurrence type

PFS (months)

OS (months)

1

–12

N

N

N

CR

IDR

44.8

71.9

2

20

N

N

N

N

N

CR

IDR

15.6

30.0

3

26

N

N

N

N

N

PD

IDR

12.0

60.9

4

34

N

N

N

N

N

N

CR

IDR

28.7

61.2

5

20

N

N

N

N

CR

No

58.8

58.8

6

–4

N

N

N

N

N

N

CR

IDR

24.7

46.2

7

−11

N

N

N

N

CR

IDR

20.1

31.3

8

19

N

N

N

N

First↓then↑

CR

No

34.1

34.3

9

45

N

N

N

N

N

CR

IDR

17.1

34.3

10

48

N

N

N

N

SD

LTP

13.0

23.9

11

48

N

N

N

N

N

CR

No

23.3

23.3

12

60

N

N

N

N

N

First↓then↑

PD

LTP

4.2

15.1

13

13

N

N

N

N

N

CR

No

16.9

16.9

14

41

N

N

First↓then↑

PD

IDR

2.8

18.5

15

55

N

N

N

N

N

CR

No

22.5

22.5

Total4

26 (4–60)

/

/

/

/

/

4/11

11/0/1/3

2/8/5

20.1 (2.8–45.1)

31.3 (15.1–71.9)

  1. 1 AST: aspartate aminotransferase; ALT: alanine aminotransferase; T-BIL: total bilirubin; AFP: alpha-fetoprotein; PFS: progression-free survival; OS: overall survival; ALBI: albumin–bilirubin; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease; LTP: local tumor progression; IDR: intrahepatic distant recurrence
  2. 2 Here, a positive value indicates RFA was performed before SBRT, while negative values indicate that SBRT was performed before RFA
  3. 3 The tumor response was evaluated one year after the latter treatment (either RFA or SBRT)
  4. 4 In this line, the order of ALBL is abnormal and normal. The order of tumor response is CR, PR, SD, and PD. The order of recurrence type is LTP, IDR, and no recurrence. The value of treatment intervals, PFS, and OS are displayed as median and range