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Fig. 11 | BMC Cancer

Fig. 11

From: Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma

Fig. 11

Validation of expression of hub genes in hepatoblastoma and effects of NOTUM on tumor growth. (A) Western blot for (B) AXIN2, (C) LAMB1, (D) NOTUM and (E) SERPINC1 proteins in hepatoblastoma and adjacent normal tissues. (F, G) Immunohistochemistry of NOTUM protein in hepatoblastoma as well as normal tissues. Bar = 50 μm. (H-J) Western blot for NOTUM expression in HuH-6 and HepG2 cells transfected with sh-NOTUM or NC. (K, L) Tumor volume was measured every 4 days in nude mice injected with HuH-6 or HepG2 cells transfected with sh-NOTUM or NC. (M-P) Tumor weight was measured in nude mice injected with HuH-6 or HepG2 cells transfected with sh-NOTUM or NC after 21 days. *p < 0.05; **p < 0.01; ****p < 0.0001

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