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Table 3 The comparison between four related research and our study

From: Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer

Item/Study

Li H et al

Wang D et al

Zhu L et al

Wu Z et al

Ours

PMID

33,672,990

34,059,009

34,222,241

33,947,836

NA

Publishing date

2021.02

2021.06

2021.07

2021.05

NA

FR gene set

60

60

259

259

256

Species of FRGs

Human

Human

Human/Mice

/Drosophila

Human/Mice

/Drosophila

Human

Risk signature

8

9

11

15

8

Grouping criterion

Median

Median

Median

Median

Optimal cutoff value

ROC

(1Y/2Y/3Y)

None

0.618/0.653/0.663

0.7/0.749/0.72

0.719

0.702

Validation cohorts

METABRIC

(n = 1904)

GSE42568

ICGC

(n = 154)

GSE20685

GSE20711

GSE42568

(n = 519)

None

METABRIC

GSE20685

GSE58812

ICGC

(n = 2248)

Experiments in vitro

None

None

Alterations of FRGs expressions under Erastin inducing

None

SQLE biofunctions

Data screening

None

Exclude samples follow up with 0 day

None

None

Exclude samples follow up less than 30 days

  1. FR ferroptosis-related, FRGs ferroptosis-related genes, NA not applicable, 1Y/2Y/3Y time-dependent ROC, AUC at 1-year/2-year/3-year