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Table 4 Grade 3 ≤ adverse events during the second-line chemotherapy

From: Second-line chemotherapy after early disease progression during first-line chemotherapy containing bevacizumab for patients with metastatic colorectal cancer

Adverse event

BBP group (%)

Non-BBP group (%)

Hematological

 Neutropenia

6 (16.2)

6 (24.0)

 Anemia

1 (2.7)

4 (16.0)

 Thrombocytopenia

1 (2.7)

1 (4.0)

Non-hematological

 Fatigue

0 (0)

1 (4.0)

 Decreased appetite

2 (5.4)

2 (8.0)

 Diarrhea

2 (5.4)

0 (0)

 Hypertension

1 (2.7)

0 (0)

 Proteinuria

1 (2.7)

0 (0)

 Gastrointestinal perforation

1 (2.7)

1 (4.0)

 Bleeding

1 (2.7)

1 (4.0)

 Venous thromboembolic

1 (2.7)

0 (0)

 Cerebral infarction

1 (2.7)

0 (0)

 Ileus

1 (2.7)

1 (4.0)

 Hepatic infection

0 (0)

1 (4.0).

 Febrile neutropenia

1 (2.7)

0 (0)