Fig. 2

Oncoprint visualization of genetic alterations (i.e., inframe, missense, splice and truncating mutations, fusions, amplifications, and deep deletions) of the PTEN gene in breast cancer. In this analysis involving two different datasets available at cbioportal.org (patients n = 4265; samples n = 4427), truncating mutations and deep deletions were the most frequent alterations. Taken together, in 315 (7.4%) of the patients the queried gene was found to be altered. Each column represents a patient/sample and was sorted for the magnitude of alteration types in the queried genes. The types of alterations and the study of origin are color-coded as shown in the legend; the blue and red rectangles refer to the METABRIC and MSK studies, respectively