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Fig. 6 | BMC Cancer

Fig. 6

From: Ganglioside-monosialic acid (GM1) for prevention of chemotherapy-induced peripheral neuropathy: a meta-analysis with trial sequential analysis

Fig. 6

TSA for taxane-induced peripheral neuropathy showing that the cumulative z-curve (dark green line) has crossed the upper (superiority) TSMB (red line) for statistical significance, but does not reach the required information size (RIS) (vertical red line) (A). TSA for oxaliplatin-induced peripheral neuropathy showing that the cumulative z-curve (dark green line) has crossed neither any TSMB (red line) for benefit nor the RIS, finally stays in the nonsignificant area (B, C, D). Of note, the result of the DEB-NTC measure shows that the cumulative sample size in the included studies (133 + 126 = 259) was far less than the RIS of 51,850, indicating that the effect of GM1 on oxaliplatin-induced peripheral neuropathy was far from conclusive

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