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Table 3 : list of available targeted therapies and corresponding mechanisms of action

From: Molecular profiling of advanced soft-tissue sarcomas: the MULTISARC randomized trial

Drugs

Molecular targets

Ceritinib

ALK

ROS

Capmatinib

MET

Lapatinib

ERBB2

EGFR

Nilotinib

KIT

PDGFRA

CSF1R

Trametinib

KRAS, NRAS, HRAS

PTPN11

NF1

MAP 2 K

Trametinib + Dabrafenib

BRAF

Durvalumab + Olaparib

PDL1

PARP

Palbociclib

CDK4

CDK6

Glasdegib

SMO

TAS-120

FGFR