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Table 3 : list of available targeted therapies and corresponding mechanisms of action

From: Molecular profiling of advanced soft-tissue sarcomas: the MULTISARC randomized trial

Drugs Molecular targets
Ceritinib ALK
ROS
Capmatinib MET
Lapatinib ERBB2
EGFR
Nilotinib KIT
PDGFRA
CSF1R
Trametinib KRAS, NRAS, HRAS
PTPN11
NF1
MAP 2 K
Trametinib + Dabrafenib BRAF
Durvalumab + Olaparib PDL1
PARP
Palbociclib CDK4
CDK6
Glasdegib SMO
TAS-120 FGFR