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Fig. 4 | BMC Cancer

Fig. 4

From: The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy

Fig. 4

EBV and HPV infections displayed significantly changed gene expressions. A Volcano plots of differentially expressed genes (DEGs) regarding EBV-infection in STAD, HBV-infection in LIHC and HPV-infection in HNSC. DEGs are defined as genes with the absolute value of log2-fold change (|log2FC|) > 0.5 and adjust.P < 0.05. The red dots represent upregulated DEGs and the blue dots represent downregulated DEGs. The total number and |log2FC| values of DEGs regarding EBV- and HPV-infection are significantly larger than DEGs regarding HBV-infection. Nine genes are overlapped in all types of viral infection-regarding DEGs which are annotated in the figure. (B) Correlations between mRNA expressions of the nine overlapped DEGs and EBV, HPV viral expressions in STAD and HNSC, respectively (Pearson’s correlation). C Heatmap of viral infection-regarding DEGs in each gene subset for STAD, LIHC and HNSC. The color bar indicates the scale of the log2FC value for each DEG. The total number of genes in each gene subset is annotated above and the corresponding biological function are labeled with different colors. D Pathway analysis for different viral infection-regrading DEGs. Comparisons were made of enriched pathways of DEGs in different gene subsets for each cluster. Upregulated and downregulated DEGs were analyzed separately. The number of DEGs enriched in a pathway is indicated by the size of the circle and the color indicates the corresponding adjust.P value

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