Table 1 Characteristics of Asian patients with breast cancer (N = 311)
From: Hotspot mutation profiles of AKT1 in Asian women with breast and endometrial cancers
Total | AKT1 mutation status | p | ||
|---|---|---|---|---|
N = 311 (%) | Wild-type n = 288 (%) | Mutated n = 23 (%) | ||
Median age (range; y) | 52 (22–90) | 52 (22–90) | 48 (32–67 | 0.22 |
Initial TNM Stage | 0.83 | |||
IA | 71 | 66 (24) | 5 (24) | |
IB | 2 | 2 (1) | 0 (0) | |
IIA | 68 | 65 (23) | 3 (14) | |
IIB | 59 | 53 (19) | 5 (24) | |
IIIA | 46 | 42 (15) | 4 (19) | |
IIIB | 12 | 10 (4) | 2 (10) | |
IIIC | 16 | 15 (5) | 1 (5) | |
IV | 28 | 27 (10) | 1 (5) | |
ND | 10 | 8 (4) | 2 (9) | |
Histology | 0.17 | |||
IDC | 284 | 266 (92) | 18 (78) | |
ILC | 11 | 9 (3) | 2 (9) | |
ND | 16 | 13 (5) | 3 (13) | |
Grade | 0.88 | |||
1 | 31 | 29 (10) | 2 (9) | |
2 | 146 | 135 (47) | 11 (48) | |
3 | 116 | 109 (38) | 7 (30) | |
ND | 18 | 15 (5) | 3 (13) | |
Lymphovascular invasion | 0.15 | |||
Positive | 130 | 117 (41) | 13 (57) | |
Negative | 121 | 115 (40) | 6 (26) | |
ND | 60 | 56 (19) | 4 (17) | |
Hormone Receptor | 0.94 | |||
Positive | 264 | 249 (86) | 20 (87) | |
Negative | 47 | 39 (14) | 3 (13) | |
HER2 status | 0.08 | |||
Positive | 55 | 54 (19) | 1 (4) | |
Negative* | 256 | 234 (81) | 22 (96) | |