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Table 2 Self-reported questionnaires used in study

From: “Chronic fatigue, quality of life and long-term side-effects of chemotherapy in patients treated for non-epithelial ovarian cancer: national case-control protocol study of the GINECO-Vivrovaire rare tumors INCa French network for rare malignant ovarian tumors”

Questionnaires

Scoring

Definition of scoring

Chronic fatigue

Fatigue

MFI-20 items

5 dimensions of fatigue:

-General fatigue

-Physical fatigue

-Reduced motivation

-Reduced activity

-Mental fatigue

High score indicates high level of fatigue

Global quality of lifea

Global QoL

FACT-G

4 dimensions: 0–4 Likert scale

- PWB: 7 items, score range: 0–28

- SWB: 7 items, score range: 0–28

- EWB: 6 items, score range: 0–24

- FWB: 7 items, score range: 0–28

Total score: 0–108

A lower score indicates a lower QoL dimension

Additional concerns subscalea

EOC specific concerns

FACT-O

0–4 Likert scale

Score: 0–44

A lower score indicates a severe symptom

 

A lower score indicates a high level of fatigue

Neurotoxicity

FACT/GOG-Ntx

0–4 Likert scale

Score range: 0–44

A lower score indicates a worse neuropathy

Score < 33 ≈ Severe neuropathy

TOI = PWB + FWB + concerns subscalea

 FACT-F/TOI

Score range: 0–108

A lower score indicates a severe symptom

 FACT/GOG-Ntx/TOI

Score range: 0–100

 FACT-Cog

Score range: 0–100

 FACT-O/ TOI

Score range: 0–100

Other dimensions of QoL

Anxiety & Depression

HADS

Anxiety: 7 items, score range: 0–21

Depression:7 items, score range: 0–21

Score ≥ 8 ≈ elevated anxiety,

Score ≥ 8 ≈ elevated depression,

Sleep disturbance

ISI

0–5 Likert scale

Score range: 0–28

A higher total score indicates more severe sleep difficulties

Score 22–28 ≈ Severe clinical insomnia

Physical activity

IPAQ

3 levels of physical activity (categorical score)b

High/ moderate/low level of physical activity

Conditions of life

Living conditions questionnaire [25]

Daily life of participants (family, social and professional situation)

NA

Assessment and comparison of the costs of sequelae in the 2 groups of patients

Euroqol (EQ-5D 5 L) questionnaire

Generic measure for clinical and economic assessment

Utility score associated with state of health.

  1. a: Clinically significant difference: variation of 5%, b: Responses are categorized into three levels of physical activity: low (<moderate); moderate (3 or more days/week of vigorous activity of at least 20 min/day or 5 or more days/week of moderate activity, or 30 min/day walking) and high (vigorous activity on at least 3 days or 7 days/week of any combination of walking, moderate or vigorous intensity activities). MFI Multidimensional Fatigue Inventory -QoL Quality of Life, FACT-G General Functional Assessment of Cancer Therapy, PWB Physical Well-Being, SWB Social/family Well-Being, EWB Emotional Well-Being, FWB Functional Well-Being, EOC Epithelial Ovarian Cancer, FACT-O Functional Assessment of Chronic Therapy- Ovarian subscale, FACT-F Functional Assessment of Chronic Therapy-Fatigue subscale, FACT/GOG-Ntx Functional Assessment of Cancer Therapy/ Gynecologic Oncology Group–Neurotoxicity subscale, FACT-Cog Functional Assessment of Cancer Therapy-Cognitive, TOI Trial Outcome Index, ISI Insomnia Severity Index, HADS Hospital Anxiety and Depression Scale, IPAQ International Physical Activity Questionnaire, NA Not Adapted