Fig. 3

The antitumor effects of BD0801, anti-PD-1, and anti-PD-L1 antibodies in the 3LL lung cancer syngeneic mouse model. (A, B) The 3LL tumor-bearing C57BL/6 mice received the vehicle, anti-PD-1 antibody or BD0801 biweekly; the tumor volume and the bodyweight are shown in (A) and (B), respectively (n = 6/group). (C) The 3LL tumor-bearing C57BL/6 mice received 0.8 mg/kg BD0801, 5 mg/kg anti-PD-1 antibody, or combination by intraperitoneal injection biweekly (n = 10/group). (D) The 3LL tumor-bearing C57BL/6 mice received 2.5 mg/kg BD0801, 5 mg/kg anti-PD-L1 antibody, or combination by intraperitoneal injection biweekly (n = 10/group). The error bars represent SEM. IP, intraperitoneal, Ab, antibody. The P-value was calculated based on the tumor volume comparing to the assigned group using two-way ANOVA; treatment group versus vehicle group: **, P < 0.01; combination treatment group versus single treatment group: #, P < 0.05, ##, P < 0.01. The tumor images are included in Supplementary Fig. S5