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Table 4 Univariate and multivariate analysis with respect to DFS, OS or DSS in TNBC

From: Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy

Disease-free survival
  Univarite analysis Multivariate analysis
 Parameters Hazard ratio 95% CI p value Hazard ratio 95% CI p value
 Age at opetation (years old) ≤ 60 vs >  60 1.002 0.491–1.925 0.994    
 Tumor size (mm) ≤ 20.0 vs > 20.0 0.924 0.434–2.277 0.850    
 Skin infiltration Negative vs Positive 2.912 1.302–5.883 0.011 2.518 1.092–5.311 0.032
 Lymph node status Negative vs Positive 1.466 0.741–3.160 0.281    
 Ki67 ≤ 14% vs > 14% 1.413 0.684–3.294 0.367    
 Objective response rate Non-Responders vs Responders 0.157 0.081–0.320 < 0.001 0.213 0.102–0.462 < 0.001
 Pathological response Non-pCR vs pCR 0.286 0.122–0.590 < 0.001 0.427 0.176–0.929 0.031
 TILs Low vs High 0.424 0.218–0.797 0.008 0.661 0.330–1.288 0.226
 Body mass index (kg/m2) ≤ 18.5 vs > 18.5 0.457 0.227–1.022 0.056 0.604 0.290–1.377 0.218
 Body mass index (kg/m2) ≤ 25.0 vs > 25.0 0.565 0.213–1.251 0.170    
 Body mass index (kg/m2) ≤ 30.0 vs > 30.0 0.775 0.044–3.577 0.794    
Overall survival
  Univarite analysis Multivariate analysis
 Parameters Hazard ratio 95% CI p value Hazard ratio 95% CI p value
 Age at opetation (years old) ≤ 60 vs > 60 0.722 0.236–1.844 0.514    
 Tumor size (mm) ≤ 20.0 vs > 20.0 0.836 0.309–2.907 0.752    
 Skin infiltration Negative vs Positive 4.423 1.675–10.643 0.004 3.957 1.395–10.667 0.011
 Lymph node status Negative vs Positive 2.741 0.927–11.706 0.071 2.794 0.908–12.208 0.076
 Ki67 ≤ 14% vs > 14% 2.090 0.707–8.928 0.199    
 Objective response rate Non-Responders vs Responders 0.088 0.036–0.213 < 0.001 0.104 0.037–0.294 < 0.001
 Pathological response Non-pCR vs pCR 0.129 0.020–0.446 < 0.001 0.246 0.038–0.913 0.035
 TILs Low vs High 0.376 0.142–0.905 0.028 0.813 0.284–2.201 0.685
 Body mass index (kg/m2) ≤ 18.5 vs > 18.5 0.299 0.124–0.788 0.017 0.645 0.248–1.832 0.393
 Body mass index (kg/m2) ≤ 25.0 vs > 25.0 1.035 0.338–2.643 0.947    
 Body mass index (kg/m2) ≤ 30.0 vs > 30.0 0.266    
Disease specific survival
  Univarite analysis Multivariate analysis
 Parameters Hazard ratio 95% CI p value Hazard ratio 95% CI p value
 Age at opetation (years old) ≤ 60 vs > 60 0.722 0.236–1.844 0.514    
 Tumor size (mm) ≤ 20.0 vs > 20.0 0.836 0.309–2.907 0.752    
 Skin infiltration Negative vs Positive 4.423 1.675–10.643 0.004 3.957 1.395–10.667 0.011
 Lymph node status Negative vs Positive 2.741 0.927–11.706 0.071 2.794 0.908–12.208 0.076
 Ki67 ≤ 14% vs > 14% 2.090 0.707–8.928 0.199    
 Objective response rate Non-Responders vs Responders 0.088 0.036–0.213 < 0.001 0.104 0.037–0.294 < 0.001
 Pathological response Non-pCR vs pCR 0.129 0.020–0.446 < 0.001 0.246 0.038–0.913 0.035
 TILs Low vs High 0.376 0.142–0.905 0.028 0.813 0.284–2.201 0.685
 Body mass index (kg/m2) ≤ 18.5 vs > 18.5 0.299 0.124–0.788 0.017 0.645 0.248–1.832 0.393
 Body mass index (kg/m2) ≤ 25.0 vs > 25.0 1.035 0.338–2.643 0.947    
 Body mass index (kg/m2) ≤ 30.0 vs > 30.0 0.266    
  1. DFS disease-free survival, OS overall survival, DSS disease specific survival, TNBC triple negative breast cancer, CI confidence intervals, pCR pathological complete response, TILs tumor-infiltrating lymphocytes