Skip to main content

Table 4 Univariate and multivariate analysis with respect to DFS, OS or DSS in TNBC

From: Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy

Disease-free survival

 

Univarite analysis

Multivariate analysis

 Parameters

Hazard ratio

95% CI

p value

Hazard ratio

95% CI

p value

 Age at opetation (years old) ≤ 60 vs >  60

1.002

0.491–1.925

0.994

   

 Tumor size (mm) ≤ 20.0 vs > 20.0

0.924

0.434–2.277

0.850

   

 Skin infiltration Negative vs Positive

2.912

1.302–5.883

0.011

2.518

1.092–5.311

0.032

 Lymph node status Negative vs Positive

1.466

0.741–3.160

0.281

   

 Ki67 ≤ 14% vs > 14%

1.413

0.684–3.294

0.367

   

 Objective response rate Non-Responders vs Responders

0.157

0.081–0.320

< 0.001

0.213

0.102–0.462

< 0.001

 Pathological response Non-pCR vs pCR

0.286

0.122–0.590

< 0.001

0.427

0.176–0.929

0.031

 TILs Low vs High

0.424

0.218–0.797

0.008

0.661

0.330–1.288

0.226

 Body mass index (kg/m2) ≤ 18.5 vs > 18.5

0.457

0.227–1.022

0.056

0.604

0.290–1.377

0.218

 Body mass index (kg/m2) ≤ 25.0 vs > 25.0

0.565

0.213–1.251

0.170

   

 Body mass index (kg/m2) ≤ 30.0 vs > 30.0

0.775

0.044–3.577

0.794

   

Overall survival

 

Univarite analysis

Multivariate analysis

 Parameters

Hazard ratio

95% CI

p value

Hazard ratio

95% CI

p value

 Age at opetation (years old) ≤ 60 vs > 60

0.722

0.236–1.844

0.514

   

 Tumor size (mm) ≤ 20.0 vs > 20.0

0.836

0.309–2.907

0.752

   

 Skin infiltration Negative vs Positive

4.423

1.675–10.643

0.004

3.957

1.395–10.667

0.011

 Lymph node status Negative vs Positive

2.741

0.927–11.706

0.071

2.794

0.908–12.208

0.076

 Ki67 ≤ 14% vs > 14%

2.090

0.707–8.928

0.199

   

 Objective response rate Non-Responders vs Responders

0.088

0.036–0.213

< 0.001

0.104

0.037–0.294

< 0.001

 Pathological response Non-pCR vs pCR

0.129

0.020–0.446

< 0.001

0.246

0.038–0.913

0.035

 TILs Low vs High

0.376

0.142–0.905

0.028

0.813

0.284–2.201

0.685

 Body mass index (kg/m2) ≤ 18.5 vs > 18.5

0.299

0.124–0.788

0.017

0.645

0.248–1.832

0.393

 Body mass index (kg/m2) ≤ 25.0 vs > 25.0

1.035

0.338–2.643

0.947

   

 Body mass index (kg/m2) ≤ 30.0 vs > 30.0

–

–

0.266

   

Disease specific survival

 

Univarite analysis

Multivariate analysis

 Parameters

Hazard ratio

95% CI

p value

Hazard ratio

95% CI

p value

 Age at opetation (years old) ≤ 60 vs > 60

0.722

0.236–1.844

0.514

   

 Tumor size (mm) ≤ 20.0 vs > 20.0

0.836

0.309–2.907

0.752

   

 Skin infiltration Negative vs Positive

4.423

1.675–10.643

0.004

3.957

1.395–10.667

0.011

 Lymph node status Negative vs Positive

2.741

0.927–11.706

0.071

2.794

0.908–12.208

0.076

 Ki67 ≤ 14% vs > 14%

2.090

0.707–8.928

0.199

   

 Objective response rate Non-Responders vs Responders

0.088

0.036–0.213

< 0.001

0.104

0.037–0.294

< 0.001

 Pathological response Non-pCR vs pCR

0.129

0.020–0.446

< 0.001

0.246

0.038–0.913

0.035

 TILs Low vs High

0.376

0.142–0.905

0.028

0.813

0.284–2.201

0.685

 Body mass index (kg/m2) ≤ 18.5 vs > 18.5

0.299

0.124–0.788

0.017

0.645

0.248–1.832

0.393

 Body mass index (kg/m2) ≤ 25.0 vs > 25.0

1.035

0.338–2.643

0.947

   

 Body mass index (kg/m2) ≤ 30.0 vs > 30.0

–

–

0.266

   
  1. DFS disease-free survival, OS overall survival, DSS disease specific survival, TNBC triple negative breast cancer, CI confidence intervals, pCR pathological complete response, TILs tumor-infiltrating lymphocytes