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Fig. 5 | BMC Cancer

Fig. 5

From: Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner

Fig. 5

Interrupt of Trp metabolism/c-Myc loop improved the outcome of chemotherapy in prostate cancer. A, tumor volumes of LNCaP bearing mice treated with PBS, Abi, Mycro 3 and Abi combing Mycro 3. B, survival time of LNCaP bearing mice treated with PBS, Abi, Mycro 3 and Abi combing Mycro 3. C, tumor volumes of LNCaP bearing mice treated with PBS, Doc, Mycro 3 and Doc combing Mycro 3. D, survival time of LNCaP bearing mice treated with PBS, Doc, Mycro 3 and Doc combing Mycro 3. E, tumor volumes of c-Myc overexpression LNCaP bearing mice treated with PBS, Abi, Mycro 3 and Abi combing Mycro 3. F, survival time of c-Myc overexpression LNCaP bearing mice treated with PBS, Abi, Mycro 3 and Abi combing Mycro 3. G, schematic diagram of Trp metabolism/c-Myc induced drugs resistance in prostatic cancer

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BMC Cancer

ISSN: 1471-2407

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