Fig. 2

Kyn promoted the activation of AhR signals to mediate drugs resistance. A, western blotting of AhR in LNCaP/VCaP cells treated with PBS or 200 μM Kyn. B, cytotoxicity of Kyn (200 μM) cultured LNCaP/VCaP cells treated with PBS or AhR antagonist 2 (2 nM) to Abi (10 μM). C, cytotoxicity of Kyn (200 μM) cultured LNCaP/VCaP cells treated with PBS or AhR antagonist 2 (2 nM) to Doc (1 μg/ml). D, immunofluorescence staining of AhR in prostatic tumor tissues from chemo-sensitive (C-S) and chemo-resistant (C-R) patients (n = 10 per groups)