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Table 2 Suggested dose constraints of organs at risk

From: POstmastectomy radioThErapy in Node-posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a study protocol for a multicenter prospective phase III randomized controlled trial

Organs at risk

43.5 Gy in 15 fractions

50 Gy in 25 fractions

Heart (left-sided breast cancer)

Dmean < 8 Gy

Dmean < 10 Gy

 

V5 < 45%

V5 < 50%

Heart (right-sided breast cancer)

Dmean < 5 Gy

Dmean < 6 Gy

 

V5 < 30%

V5 < 35%

Left anterior descending coronary artery

V40 < 2 0%

V40 < 20%

Right coronary artery

V40 < 20%

V40 < 20%

Ipsilateral lung

Dmean < 15 Gy

Dmean < 15 Gy

 

V20 < 30%

V20 < 30%

 

V5 < 55%

V5 < 55%

Contralateral lung

V5 < 20%

V5 < 20%

Contralateral breast

Dmean < 5 Gy

Dmean < 5 Gy

Spinal Cord PRV

Dmax < 30 Gy

Dmax < 40 Gy

Esophagus/Ipsilateral Brachial plexus

Dmax < 48 Gy

Dmax < 55 Gy

Ipsilateral shoulder joint

V30 < 30%

V30 < 30%

Thyroid gland

Dmean < 28 Gy

Dmean < 3 0 Gy

Liver (right-sided breast cancer)

V5 < 25%

V5 < 25%

Stomach (left-sided breast cancer)

V 5 < 25%

V5 < 25%

Liver (left-sided breast cancer)

V5 < 10%

V5 < 10%

Stomach (right-sided breast cancer)

V5 < 10%

V5 < 10%

  1. Abbreviations: Dmean, mean dose; Vx, percent volume of the structure receiving x Gy; Dmax, maximal dose