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Fig. 1 | BMC Cancer

Fig. 1

From: Effects of dezocine on morphine tolerance and opioid receptor expression in a rat model of bone cancer pain

Fig. 1

Establishment of a bone cancer pain model. A. Behavioral tests of nociception in the groups. Defense times were measured in three groups: the control group (n = 8; skin incision only), sham group (n = 8; intratibial injection of normal saline only), and BCP group (n = 54; intratibial injection of cancer cells). BCP: bone cancer pain. Data are expressed as the mean ± SEM, and two-way analysis of variance (ANOVA) was used, followed by the Bonferroni test. *P < 0.05 compared with the control group. #P < 0.05 compared with the sham group. B. Pathological examination (H&E staining) of ipsilateral bone tissues in the rats in the BCP group. Scale bar = 100 μm, 200 μm

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