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Table 3 Stratified analysis of the association of HBV infection with the risk of CRC

From: Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study

  HBsAg Seronegative HBsAg Seropositive Adjusted Hazard Ratios
(95% CI)
P for interaction
Cases Person-years Cases Person-years
Sex a 0.6045
Women 61 216,063 3 4264 2.31(0.71 ~ 7.50)  
Men 369 826,442 15 24,352 1.75(1.04 ~ 2.94)  
Age (years) b 0.2749
Age ≤ 45 20 317,261 2 10,746 2.74(0.64 ~ 11.85)  
45 < Age ≤ 65 280 591,855 14 15,537 1.95(1.14 ~ 3.34)  
Age > 65 130 133,340 2 2334 0.87(0.21 ~ 3.51)  
BMI (Kg/m2) c 0.1009
BMI < 24 154 408,823 10 11,149 2.72(1.43–5.16)  
24 ≤ BMI<28 186 438,055 6 12,174 1.42(0.63 ~ 3.22)  
BMI ≥ 28 90 195,626 2 5292 0.94(0.23 ~ 3.82)  
Current smoker d 0.0247
No 298 719,868 7 18,797 1.05(0.50 ~ 2.22)  
Yes 132 322,638 11 9820 3.20(1.73 ~ 5.95)  
Current drinker e
No 321 854,353 17 23,686 2.26(1.38 ~ 3.68) 0.0892
Yes 109 188,153 1 4930 0.39(0.06 ~ 2.81)  
  1. Note:
  2. All models were adjusted for hypercholesterolemia, hypertriglyceridemia, hs-CRP (< 1 mg/L, 1–3 mg/L, > 3 mg/L), hyperbilirubinemia, elevated alanine aminotransferase, diabetes, family income, educational background, marital status, salt consumption, physical activity and family history of cancer
  3. aAge (every 10 years), BMI (normal, overweight, obesity), current smoker and drinking status were further adjusted when participants were stratified by sex
  4. bSex, BMI (normal, overweight, obesity), current smoker and drinking status were further adjusted when participants were stratified by age. Age was also adjusted within each age stratum to prevent residual confounding
  5. cAge (every 10 years), sex, current smoker and drinking status were further adjusted when participants were stratified by BMI
  6. dAge (every 10 years), BMI (normal, overweight, obesity), sex and drinking status were further adjusted when participants were stratified by smoking status
  7. eAge (every 10 years), BMI (normal, overweight, obesity), sex and smoking status were further adjusted when participants were stratified by drinking status