| |
HBsAg Seronegative
|
HBsAg Seropositive
|
Adjusted Hazard Ratios
(95% CI)
|
P for interaction
|
|---|
|
Cases
|
Person-years
|
Cases
|
Person-years
|
|---|
|
Sex a
|
0.6045
|
|
Women
|
61
|
216,063
|
3
|
4264
|
2.31(0.71 ~ 7.50)
| |
|
Men
|
369
|
826,442
|
15
|
24,352
|
1.75(1.04 ~ 2.94)
| |
|
Age (years) b
|
0.2749
|
|
Age ≤ 45
|
20
|
317,261
|
2
|
10,746
|
2.74(0.64 ~ 11.85)
| |
|
45 < Age ≤ 65
|
280
|
591,855
|
14
|
15,537
|
1.95(1.14 ~ 3.34)
| |
|
Age > 65
|
130
|
133,340
|
2
|
2334
|
0.87(0.21 ~ 3.51)
| |
|
BMI (Kg/m2) c
|
0.1009
|
|
BMI < 24
|
154
|
408,823
|
10
|
11,149
|
2.72(1.43–5.16)
| |
|
24 ≤ BMI<28
|
186
|
438,055
|
6
|
12,174
|
1.42(0.63 ~ 3.22)
| |
|
BMI ≥ 28
|
90
|
195,626
|
2
|
5292
|
0.94(0.23 ~ 3.82)
| |
|
Current smoker d
|
0.0247
|
|
No
|
298
|
719,868
|
7
|
18,797
|
1.05(0.50 ~ 2.22)
| |
|
Yes
|
132
|
322,638
|
11
|
9820
|
3.20(1.73 ~ 5.95)
| |
|
Current drinker e
|
|
No
|
321
|
854,353
|
17
|
23,686
|
2.26(1.38 ~ 3.68)
|
0.0892
|
|
Yes
|
109
|
188,153
|
1
|
4930
|
0.39(0.06 ~ 2.81)
| |
- Note:
- All models were adjusted for hypercholesterolemia, hypertriglyceridemia, hs-CRP (< 1 mg/L, 1–3 mg/L, > 3 mg/L), hyperbilirubinemia, elevated alanine aminotransferase, diabetes, family income, educational background, marital status, salt consumption, physical activity and family history of cancer
- aAge (every 10 years), BMI (normal, overweight, obesity), current smoker and drinking status were further adjusted when participants were stratified by sex
- bSex, BMI (normal, overweight, obesity), current smoker and drinking status were further adjusted when participants were stratified by age. Age was also adjusted within each age stratum to prevent residual confounding
- cAge (every 10 years), sex, current smoker and drinking status were further adjusted when participants were stratified by BMI
- dAge (every 10 years), BMI (normal, overweight, obesity), sex and drinking status were further adjusted when participants were stratified by smoking status
- eAge (every 10 years), BMI (normal, overweight, obesity), sex and smoking status were further adjusted when participants were stratified by drinking status
