Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study

Table 2 The association of HBV infection with the risk of CRC among different regressions

	HBsAg Seronegative		HBsAg Seropositive		Adjusted Hazard Ratios (95% CI)
	Cases	Person-years	Cases	Person-years	Adjusted Hazard Ratios (95% CI)
Multivariate COX Regression
Model 1	430	1,042,506	18	28,617	1.52(0.95 ~ 2.44)
Model 2	430	1,042,506	18	28,617	1.79(1.12 ~ 2.87)
Model 3	430	1,042,506	18	28,617	1.85(1.15 ~ 2.96)
SD Model
Model 1	430	1,042,506	18	28,617	1.47(0.92 ~ 2.36)
Model 2	430	1,042,506	18	28,617	1.71(1.07 ~ 2.74)
Model 3	430	1,042,506	18	28,617	1.77(1.11 ~ 2.84)
CS Model
Model 1	430	1,042,506	18	28,617	1.50(0.94 ~ 2.40)
Model 2	430	1,042,506	18	28,617	1.74(1.11 ~ 2.78)
Model 3	430	1,042,506	18	28,617	1.79(1.13 ~ 2.91)

Note:
Model 1: Univariate analysis
Model 2: Adjusted for age (every 10 years), sex based on model 1
Model 3: Further adjusted for BMI (normal, overweight, obesity), hypercholesterolemia, hypertriglyceridemia, hs-CRP (< 1 mg/L, 1–3 mg/L, > 3 mg/L), hyperbilirubinemia, elevated alanine aminotransferase, diabetes, family income, educational background, marital status, salt consumption, current smoker, drinking status, physical activity and family history of cancer based on model 2
CS model Cause-specific hazard model, SD model Sub-distribution hazard function model

ISSN: 1471-2407