Skip to main content

Table 2 Hazard ratio of overall survival in melanoma patients based on gender, age at diagnosis of melanoma and interval from first melanoma to SPC diagnosis

From: Types of second primary cancer influence overall survival in cutaneous melanoma

Gender

Age at diagnosis (years old)

No SPC

Interval from first melanoma diagnosis to SPC

< 1 year

1–5 year

6–10 year

>  10 year

N

HR (95% CI)

N

HR (95% CI)

N

HR (95% CI)

N

HR (95% CI)

N

HR (95% CI)

Second melanoma

Males

< 60

1304

Reference

20

2.41 (1.54–3.77)

36

2.81 (2.00–3.94)

10

0.87 (0.47–1.63)

13

0.63 (0.36–1.11)

60–79

3189

2.96 (2.76–3.16)

59

3.98 (3.12–5.07)

72

4.39 (3.47–5.56)

48

4.75 (3.64–6.19)

27

4.76 (3.33–6.80)

≥80

1677

8.17 (7.53–8.86)

30

7.57 (5.41–10.6)

30

11.1 (7.90–15.6)

8

7.16 (4.57–11.2)

  

Females

< 60

840

Reference

6

1.37 (0.59–3.18)

14

1.64 (0.94–2.87)

3

0.42 (0.14–1.29)

5

0.28 (0.12–0.68)

60–79

2062

4.23 (3.89–4.59)

24

5.09 (3.39–7.63)

33

6.19 (4.34–8.84)

17

5.92 (3.66–9.57)

16

6.08 (3.85–9.60)

≥80

1964

14.3 (13.1–15.7)

23

15.9 (10.6–23.9)

25

17.2 (12.0–24.5)

9

19.9 (11.1–35.8)

2

22.4 (9.66–52.1)

Other SPC

Males

< 60

1304

Reference

15

5.16 (2.95–9.02)

59

3.71 (2.77–4.97)

65

3.61 (2.79–4.67)

100

2.90 (2.30–3.66)

60–79

3189

2.96 (2.77–3.17)

108

7.65 (6.21–9.43)

443

7.20 (6.42–8.08)

309

7.40 (6.52–8.39)

201

8.18 (7.03–9.51)

≥80

1677

8.29 (7.65–8.98)

57

13.5 (10.7–17.1)

174

11.9 (10.2–13.9)

44

14.2 (10.6–19.1)

3

10.0 (2.80–35.9)

Females

< 60

840

Reference

15

4.89 (2.77–8.64)

66

5.97 (4.5–7.91)

65

4.56 (3.47–6.00)

104

3.81 (3.04–4.77)

60–79

2062

4.25 (3.91–4.61)

51

13.0 (9.26–18.4)

213

11.7 (9.9–13.7)

181

11.9 (9.94–14.3)

125

15.3 (12.3–19.1)

≥80

1964

14.5 (13.2–15.8)

36

17.6 (12.2–25.3)

136

22.5 (18.8–27.1)

40

16.4 (11.8–23.0)

8

17.4 (8.14–37.4)

  1. N number of death, HR hazard ratio, CI confidence interval, SPC second primary cancer