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Table 3 Clinicopathological characteristics according to the level of γ-GT

From: Exploring the clinical value of preoperative serum gamma-glutamyl transferase levels in the management of patients with hepatocellular carcinoma receiving postoperative adjuvant transarterial chemoembolization

Characteristic

γ-GT ≤ 54 U/L

(n = 947)

γ-GT > 54 U/L

(n = 900)

P-value

Age (years)

Mean ± SD

52.3 (10.5)

52.1 (10.6)

0.778

Sex

Female

182 (19.2%)

90 (10.0%)

< 0.001

 

Male

765 (80.8%)

810 (90.0%)

 

HBV infection

No

139 (14.7%)

103 (11.4%)

0.047

 

Yes

808 (85.3%)

797 (88.6%)

 

Cirrhosis

No

315 (33.3%)

295 (32.8%)

0.863

 

Yes

632 (66.7%)

605 (67.2%)

 

TBil (μmol/L)

Mean ± SD

14.2 (5.54)

15.1 (6.78)

0.003

Child-pugh

A

925 (97.7%)

826 (91.8%)

< 0.001

 

B

22 (2.3%)

74 (8.2%)

 

AFP (ng/mL)

≤400

662 (69.9%)

593 (65.9%)

0.072

 

> 400

285 (30.1%)

307 (34.1%)

 

Transfusion

No

926 (97.8%)

813 (90.3%)

< 0.001

 

Yes

21 (2.2%)

87 (9.7%)

 

Tumor number

Single

799 (84.4%)

700 (77.8%)

< 0.001

 

Multiple

148 (15.6%)

200 (22.2%)

 

Tumor diameter (cm)

Mean ± SD

4.60 (2.64)

7.17 (4.33)

< 0.001

ES grading

I/II

99 (10.5%)

73 (8.1%)

0.097

 

III/IV

848 (89.5%)

827 (91.9%)

 

Capsule

Present

770 (81.3%)

717 (79.7%)

0.405

 

Absent

177 (18.7%)

183 (20.3%)

 

Satellite

No

572 (60.4%)

499 (55.4%)

0.035

 

Yes

375 (39.6%)

401 (44.6%)

 

MVI

Present

311 (32.8%)

333 (37.0%)

0.068

 

Absent

636 (67.2%)

567 (63.0%)

 

BCLC

0

79 (8.3%)

28 (3.1%)

< 0.001

 

A

755 (79.8%)

691 (76.8%)

 
 

B

113 (11.9%)

181 (20.1%)

 

AJCC

Ia

79 (8.3%)

28 (3.1%)

< 0.001

 

Ib

495 (52.3%)

443 (49.2%)

 
 

II

322 (34.0%)

301 (33.4%)

 
 

IIIa

51 (5.4%)

128 (14.2%)

 

CNLC

Ia

549 (58.0%)

297 (33.0%)

< 0.001

 

Ib

285 (30.1%)

422 (46.9%)

 
 

IIa

90 (9.5%)

113 (12.6%)

 
 

IIb

23 (2.4%)

68 (7.6%)

 

PA-TACE

No

707 (74.7%)

628 (69.8%)

0.022

 

Yes

240 (25.3%)

272 (30.2%)

 
  1. Note: HBV hepatitis B virus, TBil total bilirubin; AFP alpha-fetoprotein; γ-GT gamma-glutamyl transferase; ES Edmondson-Steiner; MVI microvascular invasion; PA-TACE postoperative adjuvant transarterial chemoembolization; AJCC according to the 8th American joint committee on cancer staging; CNLC CNLC staging was defined according the Chinese guideline for HCC