Fig. 2

A Principal component analysis (PCA). B Heatmap shows differentially expressed genes (150 upregulated and 42 downregulated; paired t-test < 0.05, mean fold change > 1.5 or < 0.67). C Gene set enrichment analysis plots. NES, normalised enrichment score; FDR, false discovery rate. D Flow cytometry histograms show propidium iodide staining of flow sorted AML blasts pre- and post-chemotherapy from patient BB121