Table 1 Reactome top 15 enriched signaling pathways after 6-h exposure of FX-9
No. | Super-pathway | Signaling Pathway | DEGs | Entities | |
|---|---|---|---|---|---|
found | FDR | ||||
1 | IS | Interleukin-4 and Interleukin-13 signaling | 8 | 17/216 | 2.24e-05 |
2 | MR | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | 2 | 6/13 | 2.24e-05 |
3 | IS | Interleukin-10 signaling | 5 | 11/86 | 2.73e-05 |
4 | IS | Signaling by Interleukins | 17 | 29/647 | 4.07e-05 |
5 | IS | Cytokine Signaling in Immune system | 26 | 37/1108 | 7.63e-04 |
6 | GE | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2 | 5/20 | 0.002 |
7 | ST | Antagonism of Activin by Follistatin | 3 | 3/4 | 0.003 |
8 | ST | Signaling by TGFB family members | 7 | 9/114 | 0.006 |
9 | CC | Transcriptional activation of cell cycle inhibitor p21 | 1 | 3/6 | 0.008 |
10 | CC | Transcriptional activation of p53 responsive genes | 1 | 3/6 | 0.008 |
11 | IS | CLEC7A/inflammasome pathway | 1 | 3/8 | 0.015 |
12 | IS | Interleukin-1 processing | 2 | 3/8 | 0.015 |
13 | CR | Cellular Senescence | 7 | 11/200 | 0.015 |
14 | IS | NOD1/2 Signaling Pathway | 5 | 5/40 | 0.02 |
15 | IS | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 6 | 6/70 | 0.035 |