Fig. 1

Data processing and lncRNA-based early risk signature construction from candidate lncRNAs. A) Schematic diagram of data processing and construction of lncRNA-based signature; B) Volcano plot of lncRNAs expression in the TCGA training cohort. Differentially expressed gene (DEG) analysis shows 1159 up-regulated lncRNAs and 336 down-regulated lncRNAs; C) Heatmap of 1495 DEG lncRNAs in 150 HCC samples and 50 normal tissues; D) Venn plot of DEG lncRNAs and early recurrence related lncRNAs (ER lncRNAs) in the TCGA training cohort. 358 DEG lncRNAs with potential prognostic value for HCC early recurrence were identified; E) ROC plot of 7 lncRNA signatures; F) ROC plot comparison between the 15-lncRNA risk signature and the 25-lncRNA risk signature, P = 0.006