Fig. 4
Body-shape phenotypes in relation to colon cancer risk. ABSI – a body shape index (cut-offs: ≥80 in men; ≥73 in women); Apple – large-ABSI-small-HI; BMI – body mass index; CI – confidence interval; HI – hip index (cut-offs: ≥49 in men; ≥64 in women); HR – hazard ratio; NW – normal weight BMI ≥ 18.5 to < 25.0 kg/m2; OB – obese BMI ≥ 30.0 to < 45.0 kg/m2; OW – overweight BMI ≥ 25.0 to < 30.0 kg/m2; Pear – small-ABSI-large-HI; Slim – small-ABSI-small-HI; Wide – large-ABSI-large-HI; HR (95% CI) – derived from cox proportional hazards models, stratified by age and region and adjusted for BMI (for overall), height, self-reported weight change within the year preceding the visit, smoking status, alcohol consumption, physical activity, Townsend deprivation index, diet (consumption of fresh fruit and vegetables, red meat, processed meat, fibre), use of non-steroidal anti-inflammatory drugs, family history of cancer and, in women, menopausal status, use of oral contraceptives and hormonal replacement therapy and age at the last live birth (see definition of covariates in Supplementary Methods). Pairwise comparisons between “apple” and “pear” and between “wide” and “slim” phenotypes for each BMI category are included in Supplementary Table S8