Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma

Table 2 Univariate and multivariate analyses of the overall survival in patients with ccRCC

Parameters	Univariate analysis				C3 - Multivariate analysis				FN1 - Multivariate analysis
Parameters	P-value	HR	95% CI (lower/upper)		P-value	HR	95% CI (lower/upper)		P-value	HR	95% CI (lower/upper)
Age	<0.001	1.775	1.307	2.410	0.001	1.714	1.259	2.333	<0.001	1.759	1.292	2.394
> 60 vs ≤60	<0.001	1.775	1.307	2.410	0.001	1.714	1.259	2.333	<0.001	1.759	1.292	2.394
Female vs. male	0.711	1.060	0.779	1.442
Clinical stage	<0.001	3.839	2.800	5.264	0.013	2.377	1.200	4.711	0.006	2.591	1.306	5.144
III/IV vs I/II	<0.001	3.839	2.800	5.264	0.013	2.377	1.200	4.711	0.006	2.591	1.306	5.144
Pathologic T	<0.001	3.156	2.333	4.269	0.891	0.959	0.529	1.739	0.701	0.889	0.488	1.619
T3/T4 vs T1/T2	<0.001	3.156	2.333	4.269	0.891	0.959	0.529	1.739	0.701	0.889	0.488	1.619
Pathologic N	<0.001	3.857	2.089	7.124	0.027	2.049	1.085	3.871	0.036	1.980	1.044	3.755
N1 vs N0	<0.001	3.857	2.089	7.124	0.027	2.049	1.085	3.871	0.036	1.980	1.044	3.755
Pathologic M	<0.001	4.387	3.222	5.973	<0.001	2.454	1.692	3.558	<0.001	2.372	1.635	3.442
M1 vs M0	<0.001	4.387	3.222	5.973	<0.001	2.454	1.692	3.558	<0.001	2.372	1.635	3.442
C3 expression	0.001	1.900	1.321	2.731	0.032	1.498	1.036	2.166
High vs low	0.001	1.900	1.321	2.731	0.032	1.498	1.036	2.166
FN1 expression	<0.001	1.695	1.256	2.288					0.009	1.512	1.110	2.058
High vs low	<0.001	1.695	1.256	2.288					0.009	1.512	1.110	2.058

Abbreviations: ccRCC clear cell renal cell carcinoma, HR hazard ratio, CI confidence interval; Significant associations are shown in bold face in the P-value column (P < 0.05)

ISSN: 1471-2407