Fig. 4

Transcriptional level validation of hub genes. (A) Hierarchical clustering of hub genes was performed using UCSC Cancer Genomics Browser. Upregulated genes are marked in red, and downregulated genes are marked in blue. (B) The mRNA levels of the top five upregulated and the top five downregulated hub genes obtained in ccRCC samples by reviewing the GEPIA database. *P < 0.01. The samples shown under the blue bar are non-cancerous samples, and the samples shown under the red bar are ccRCC samples