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Fig. 2 | BMC Cancer

Fig. 2

From: Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma

Fig. 2

DEGs identification and enrichment analysis of hub genes. (A) DEGs with a fold change of > 2 and an adj. P-value < 0.01 were selected from the mRNA expression profiling sets GSE36895, GSE53757, and GSE66272. (B) Bubble plot of GO terms related to biological process (BP), cellular component (CC) and molecular function (MF) of upregulated DEGs and (C) downregulated DEGs. (D) Bubble plot of KEGG pathway analysis of upregulated DEGs and (E) downregulated DEGs. GO or pathway description was assigned to the y-axis and gene ratio was assigned to the x- axis axis as the proportion of differential genes in the whole gene set. The bubble size represents the gene count in a certain GO term or pathway. (F) The PPI network of DEGs was constructed using Cytoscape and DEGs with ≤3 nodes, and ≤ 3 edges were removed from the network. Each node size is indicated. (G) The most significant module obtained from the PPI network had 36 nodes and 218 edges. Upregulated genes are marked in light red, and downregulated genes are marked in light green

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