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Table 1 Demographic, anatomopathological and biological data of the cohort. Twenty-three colorectal cancer tumor tissues were included and 22 circulating tumor DNA. For 11 of the tumor tissues, non-tumor tissues close to the tumor were analyzed. The anatomopathological and biological results come from analyses carried out as part of patient management

From: The detection of specific hypermethylated WIF1 and NPY genes in circulating DNA by crystal digital PCR™ is a powerful new tool for colorectal cancer diagnosis and screening

  Tumor/non-tumor tissues pairs (n = 11) Tumor tissues (n = 12) ctDNA (n = 22)
Sex, n (%)
 Men 5 (45%) 6 (50%) 16 (73%)
 Women 6 (55%) 6 (50%) 6 (27%)
Age in years, mean (min-max)
  60 (44–79) 75 (55–84) 63 (36–82)
Location of the tumor, n (%)
 Duodenum / 1 (8%) /
 Cecum 2 (18%) 2 (17%) 2 (9%)
 Right colon 2 (18%) 6 (50%) 3 (13%)
 Transverse colon / 2 (17%) 1 (5%)
 Left colon 5 (46%) / 11 (50%)
 Rectosigmoid junction 1 (9%) 1 (8%) 1 (5%)
 Rectum 1 (9%) / 4 (18%)
Conservation, n (%)
 FFPE 8 (72%) 12 (100%) /
 Freezing 3 (28%) / /
Histology, n (%)
 ADC 11 (100%) 12 (100%) 19 (86%)
 Tubular adenoma / / 1 (5%)
 NA / / 2 (9%)
Stage, n (%)
 I 1 (9%) 2 (17%) 2 (9%)
 II 4 (37%) 5 (42%) /
 III 3 (27%) 2 (17%) /
 IV 3 (27%) 2 (17%) 20 (91%)
 ND / 1 (8%) /
Microsatellite stability, n (%)
 MSS 7 (64%) 2 (17%) 16 (72%)
 MSI 3 (27%) 10 (83%) 1 (5%)
 NA 1 (9%) / 5 (23%)
Mutational status, n (%)
KRAS mutation 3 (27%) 3 (25%) 7 (32%)
NRAS mutation / / 2 (9%)
BRAF mutation 3 (27%) 4 (33%) 1 (5%)
 Other mutations / / 1 (5%)
 No mutation 1 (9%) 5 (42%) 11 (50%)
 NA 4 (36%) / /
MLH1 methylation, n (%)
 Presence (≥ 5%) 3 (27%) 9 (75%) /
 Absence (<  5%) / 3 (25%) /
 NA 8 (73%) / 22 (100%)
  1. ADC adenocarcinoma, ctDNA circulating tumor DNA, FFPE formalin-fixed paraffin-embedded, MSS microsatellite stable, MSI microsatellite instability, NA not available