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Table 3 Comparative diagnostic performance of pre-operative standard cytology and ddPCR testing

From: Utility of droplet digital polymerase chain reaction for TERT and BRAF mutational profiling of thyroid nodules

Measure

     

**BRAFV600E + TERT +

**BRAFV600E + TERT +

Bethesda

Bethesda

BRAFV600E

TERT

BRAFV600E

Bethesda

Bethesda

IV-VI

V-VI

  

+TERT

IV-VI

V-VI

Sensitivity

72.5

70

50.0

25.0

60.0

80

80

Specificity

91.7

100

100

100

100

91.7

100

PPV*

80.6

100

100

100

100

82.1

100

NPV*

87.5

87.5

74.4

73.7

84.0

90.6

91.3

PLR

8.7

–

–

–

–

9.6

–

NLR

0.3

0.3

0.5

0.8

0.4

0.2

0.2

  1. NLR negative likelihood ratio; NPV negative predictive value; PLR positive likelihood ratio; PPV positive predictive value. *Because the sample sizes in disease positive and disease negative groups may not reflect the true population prevalence of the disease, PPV and NPV may be inaccurate. **Combined BRAF and TERT classifies test as positive if BRAFV600E and/or TERT and/or Bethesda IV-VI or V-VI is present
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BMC Cancer

ISSN: 1471-2407

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