Table 3 Example exercise protocols for different chemotherapy regimens
Chemotherapy Protocol | Intravenous Delivery Length and Method | Pre-Exercise Preparation | Exercise Duration |
|---|---|---|---|
Single-agent docetaxel (1 per 21-day cycle) | 60-min infusion | • IV access established in chair • 15-min rest after infusion start • Patient carefully transferred to cycle ergometer • Warm-up initiated | • 5-min warm-up • 35 min at target heart rate • 5–10-min cool-down |
Pertuzumab + trastuzumab + docetaxel (1 per 21-day cycle) | Pertuzumab + trastuzumab infusion over ~ 5 h for loading dose/ ~ 3 h for the second dose/ 1.5–2.5 h for subsequent doses, followed by docetaxel 60-min infusion | • Pertuzumab + trastuzumab infused at rest in chair • Docetaxel infusion initiated • 15-min rest • Patient carefully transferred to cycle ergometer • Warm-up initiated | • 5-min warm-up • 35 min at target heart rate • 5–10-min cool-down |
Single-agent paclitaxel (3 per 28-day cycle) | 60-min infusion | • IV access established in chair • Infusion initiated • 15-min rest • Patient carefully transferred to cycle ergometer • Warm-up initiated | • 5-min warm-up • 35 min at target heart rate • 5–10-min cool-down |
Single-agent nanoparticle albumin–bound (nab) paclitaxel (1 per 21-day or 3 per 28-day cycle) | 30-min infusion | • IV access established in chair • Infusion initiated • Patient carefully transferred to cycle ergometer • Warm-up & infusion initiated | • 5-min warm-up • 25 min at target heart rate • 5–10-min cool-down including IV bag flush |
Atezolizumab + nab-paclitaxel (2 per 28-day cycle + 1 nab-paclitaxel only) | Atezolizumab infusion over 60 min for loading dose/ 30 min for subsequent doses, followed by nab-paclitaxel 30-min infusion | • IV access established in chair • Atezolizumab infused in chair • Patient carefully transferred to cycle ergometer • Warm-up & infusion initiated | • 5-min warm-up • 25 min at target heart rate • 5–10-min cool-down including IV bag flush |
Atezolizumab + paclitaxel (2 per 28-day cycle + 1 paclitaxel only) | Atezolizumab infusion over 60 min for loading dose/ 30 min for subsequent doses, followed by paclitaxel 60-min infusion | • IV access established in chair • Atezolizumab infused in chair • Paclitaxel infusion initiated • 15-min rest • Patient carefully transferred to cycle ergometer • Warm-up initiated | • 5-min warm-up • 35 min at target heart rate • 5–10-min cool-down |
Trastuzumab-emtansine (1 per 21-day cycle) | 30-min infusion | • IV access established in chair • Infusion initiated • Patient carefully transferred to cycle ergometer • Warm-up initiated | • 5-min warm-up • 25 min at target heart rate • 5–10-min cool-down |
Single-agent eribulin (2 per 21-day cycle) | 2–5-min push injection | • IV access established in chair • Saline infusion • Patient carefully transferred to cycle ergometer • Warm-up completed • Push injection initiated | • 5–10-min warm-up prior to push injection • Target heart rate maintained during push injection • 10–20-min at target heart rate post-push injection • 5-min cool-down |
Single-agent vinorelbine (2 per 21-day cycle) | 10-min infusion | • IV access established in chair • Saline infusion • Patient carefully transferred to cycle ergometer • Warm-up completed • Infusion started | • 5–10-min warm-up prior to infusion • Target heart rate maintained during infusion • 10–20-min at target heart rate post-infusion • 5-min cool-down |
Single-agent carboplatin (1 per 21-day cycle) | 45-min infusion | • IV access established in chair • Infusion initiated • Patient carefully transferred to cycle ergometer • Warm-up initiated | • 5-min warm-up • 35 min at target heart rate • 5-min cool-down |
Gemcitabine + cisplatin (2 per 21-day cycle) | Gemcitabine infusion over 30–60 min, followed by saline infusion over 30–60 min, followed by 60-min cisplatin infusion | • IV access established in chair • Gemcitabine and saline infused in chair • Patient carefully transferred to cycle ergometer • Warm-up & cisplatin infusion initiated | • 5-min warm-up • 50 min at target heart rate • 5-min cool-down |
Single-agent doxorubicin (1 or 3 per 21-day cycle) | 4–10-min push injection | • IV access established in chair • Saline infusion • Patient carefully transferred to cycle ergometer • Warm-up completed • Push injection started | • 5–10-min warm-up prior to push injection • Target heart rate maintained during push injection • 10–20 min at target heart rate post-push injection • 5-min cool-down |
Doxorubicin + fluorouracil + cyclophosphamide (1 per 21-day cycle) | Doxorubicin 4–10-min push injection, followed by fluorouracil 2–5-min push injection, followed by cyclophosphamide 30-min infusion | • IV access established in chair • Saline infusion • Patient carefully transferred to cycle ergometer • Warm-up & first push injection initiated | • 5-min warm-up • 40 min at target heart rate • 5-min cool-down |