Table 3 Univariable and multivariable cox regression for analyzing the prognostic factors for esophageal cancer patients with brain metastases
Subject characteristics | Univariable | Multivariable | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age (years) | ||||
< 65 | 1 (reference) | 1 (reference) | ||
> =65 | 0.90 (0.66–1.22) | 0.499 | ||
Sex | ||||
Male | 1 (reference) | 1 (reference) | ||
Female | 1.01 (0.63–1.63) | 0.967 | ||
Race | ||||
White | 1 (reference) | 1 (reference) | ||
Black | 1.84 (0.75–4.52) | 0.184 | ||
Asian or Pacific Islander | 1.63 (0.80–3.32) | 0.182 | ||
American Indian/Alaska Native | 1.39 (0.51–3.77) | 0.516 | ||
Primary site | ||||
Upper third | 1 (reference) | 1 (reference) | ||
Middle third | 1.45 (0.34–6.13) | 0.611 | ||
Lower third | 1.14 (0.28–4.60) | 0.857 | ||
Overlapping lesion | 1.69 (0.39–7.32) | 0.484 | ||
Histology | ||||
Esophageal squamous cell carcinoma | 1 (reference) | 1 (reference) | ||
Esophageal adenocarcinoma | 0.60 (0.40–0.90) | 0.013 | 0.84 (0.55–1.29) | 0.427 |
Grade | ||||
Grade I | 1 (reference) | 1 (reference) | ||
Grade II | 0.52 (0.25–1.11) | 0.09 | ||
Grade III | 0.73 (0.36–1.51) | 0.398 | ||
Grade IV | 0.39 (0.10–1.49) | 0.169 | ||
T stage | ||||
T1 | 1 (reference) | 1 (reference) | ||
T2 | 0.38 (0.21–0.68) | 0.001 | 0.36 (0.20–0.65) | < 0.001 |
T3 | 0.63 (0.43–0.94) | 0.023 | 0.66 (0.44–0.99) | 0.047 |
T4 | 1.16 (0.80–1.68) | 0.438 | 1.21 (0.82–1.78) | 0.335 |
N stage | ||||
N0 | 1 (reference) | 1 (reference) | ||
N1 | 0.70 (0.48–1.03) | 0.073 | ||
N2 | 0.67 (0.37–1.21) | 0.183 | ||
N3 | 0.90 (0.47–1.70) | 0.74 | ||
Bone metastases | ||||
None | 1 (reference) | 1 (reference) | ||
Yes | 2.04 (1.45–2.87) | < 0.001 | 1.95 (1.34–2.83) | < 0.001 |
Liver metastases | ||||
None | 1 (reference) | 1 (reference) | ||
Yes | 1.49 (1.08–2.05) | 0.015 | 1.23 (0.87–1.74) | 0.239 |
Lung metastases | ||||
None | 1 (reference) | 1 (reference) | ||
Yes | 1.92 (1.38–2.67) | < 0.001 | 1.49 (1.03–2.16) | 0.035 |