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Table 5 The joint effects of green tea consumption with DNMT3B − 149 genotypes and DNA damage level on lung cancer risk

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables Drinking status Drinking duration in years
  Drinkers Non-drinkers > 10 ≤ 10 0
  CA/CN OR (95% CI)a CA/CN OR (95% CI)a CA/CN OR (95% CI)a CA/CN OR (95% CI)a CA/CN OR (95% CI)a
DNMT3B -149 genotypes
 TT 42/121 1.47 (0.65–3.31) 141/224 2.15 (0.96–4.79) 19/58 0.94 (0.38–2.33) 23/63 1.12 (0.45–2.77) 141/224 1.50 (0.62–3.62)
 CT 2/9 1.00 (Ref.) 5/26 1.22 (0.48–3.12) 2/5 1.00 (Ref.) 0/4 5/26 0.86 (0.32–2.33)
Test for interaction χ2 = 0.13 (1 df); p = 0.72 χ2 = 3.05 (2 df); p = 0.22
DNA damage level
 High 26/40 2.26 (1.41–3.63)** 80/89 2.75 (1.78–4.25)** 13/20 2.64 (1.82–3.83)** 13/20 2.82 (1.97–4.03)** 80/89 3.31 (2.55–4.30)**
 Moderate 10/42 1.16 (0.68–1.96) 29/83 1.77 (1.12–2.80)* 5/23 1.29 (0.82–2.05) 5/19 1.51 (0.94–2.42) 29/83 2.13 (1.38–3.29)*
 Low 8/48 1.00 (Ref.) 37/78 1.80 (1.15–2.82)* 3/20 1.00 (Ref.) 5/28 1.39 (0.88–2.17) 37/78 2.17 (1.28–3.68)*
Test for interaction χ2 = 2.25 (2 df); p = 0.32 χ2 = 2.61 (4 df); p = 0.63
  1. Abbreviation: CA/CN case numbers/control numbers; OR odds ratio; CI confidence interval; Ref. reference; df degree of freedom
  2. aData were matched by age and gender, calculated by backward stepwise log-linear regression, and adjusted for pack-years of smoked, and exposure to cooking fumes
  3. *0.01 < p < 0.05, ***p < 0.001