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Table 5 The joint effects of green tea consumption with DNMT3B − 149 genotypes and DNA damage level on lung cancer risk

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables

Drinking status

Drinking duration in years

 

Drinkers

Non-drinkers

> 10

≤ 10

0

 

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

DNMT3B -149 genotypes

 TT

42/121

1.47 (0.65–3.31)

141/224

2.15 (0.96–4.79)

19/58

0.94 (0.38–2.33)

23/63

1.12 (0.45–2.77)

141/224

1.50 (0.62–3.62)

 CT

2/9

1.00 (Ref.)

5/26

1.22 (0.48–3.12)

2/5

1.00 (Ref.)

0/4

–

5/26

0.86 (0.32–2.33)

Test for interaction

χ2 = 0.13 (1 df); p = 0.72

χ2 = 3.05 (2 df); p = 0.22

DNA damage level

 High

26/40

2.26 (1.41–3.63)**

80/89

2.75 (1.78–4.25)**

13/20

2.64 (1.82–3.83)**

13/20

2.82 (1.97–4.03)**

80/89

3.31 (2.55–4.30)**

 Moderate

10/42

1.16 (0.68–1.96)

29/83

1.77 (1.12–2.80)*

5/23

1.29 (0.82–2.05)

5/19

1.51 (0.94–2.42)

29/83

2.13 (1.38–3.29)*

 Low

8/48

1.00 (Ref.)

37/78

1.80 (1.15–2.82)*

3/20

1.00 (Ref.)

5/28

1.39 (0.88–2.17)

37/78

2.17 (1.28–3.68)*

Test for interaction

χ2 = 2.25 (2 df); p = 0.32

χ2 = 2.61 (4 df); p = 0.63

  1. Abbreviation: CA/CN case numbers/control numbers; OR odds ratio; CI confidence interval; Ref. reference; df degree of freedom
  2. aData were matched by age and gender, calculated by backward stepwise log-linear regression, and adjusted for pack-years of smoked, and exposure to cooking fumes
  3. *0.01 < p < 0.05, ***p < 0.001