Variables | Smoking status | Pack-years of smoked | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
 | Nonsmokers | Current and ever smokers | 0 | 1–39 | ≥ 40 | |||||
 | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a |
DNMT3B − 149 genotypes | ||||||||||
 TT | 83/242 | 1.09 (0.64–1.86) | 100/103 | 2.83 (1.62–4.93)*** | 83/242 | 1.09 (0.64–1.86) | 37/52 | 2.39 (1.33–4.29)** | 63/51 | 3.20 (1.80–5.67)*** |
 CT | 5/20 | 1.00 (Ref.) | 2/15 | 1.08 (0.43–2.75) | 5/20 | 1.00 (Ref.) | 0/6 | – | 2/9 | 1.46 (0.56–3.82) |
Test for interaction | χ2 = 3.64 (1 df); p = 0.06 | χ2 = 5.43 (2 df); p = 0.07 | ||||||||
DNA damage level | ||||||||||
 High | 49/100 | 1.21 (0.89–1.66) | 57/29 | 3.97 (2.63–5.98)*** | 49/100 | 1.21 (0.89–1.66) | 19/17 | 3.03 (1.86–4.96)*** | 38/28 | 4.90 (3.05–7.88)*** |
 Moderate | 15/90 | 0.66 (0.45–0.98)* | 24/35 | 2.37 (1.54–3.63)*** | 15/90 | 0.66 (0.45–0.98)* | 9/15 | 2.10 (1.21–3.65)** | 15/20 | 2.54 (1.56–4.13)*** |
 Low | 24/72 | 1.00 (Ref.) | 21/54 | 1.56 (1.03–2.35)* | 24/72 | 1.00 (Ref.) | 9/26 | 1.42 (0.86–2.36) | 12/12 | 1.68 (1.04–2.71)* |
Test for interaction | χ2 = 11.80 (2 df); p < 0.01 | χ2 = 12.42 (4 df); p = 0.01 |