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Table 4 The joint effects of smoking status with DNMT3B − 149 genotypes and DNA damage level on lung cancer risk

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables

Smoking status

Pack-years of smoked

 

Nonsmokers

Current and ever smokers

0

1–39

≥ 40

 

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

CA/CN

OR (95% CI)a

DNMT3B − 149 genotypes

 TT

83/242

1.09 (0.64–1.86)

100/103

2.83 (1.62–4.93)***

83/242

1.09 (0.64–1.86)

37/52

2.39 (1.33–4.29)**

63/51

3.20 (1.80–5.67)***

 CT

5/20

1.00 (Ref.)

2/15

1.08 (0.43–2.75)

5/20

1.00 (Ref.)

0/6

–

2/9

1.46 (0.56–3.82)

Test for interaction

χ2 = 3.64 (1 df); p = 0.06

χ2 = 5.43 (2 df); p = 0.07

DNA damage level

 High

49/100

1.21 (0.89–1.66)

57/29

3.97 (2.63–5.98)***

49/100

1.21 (0.89–1.66)

19/17

3.03 (1.86–4.96)***

38/28

4.90 (3.05–7.88)***

 Moderate

15/90

0.66 (0.45–0.98)*

24/35

2.37 (1.54–3.63)***

15/90

0.66 (0.45–0.98)*

9/15

2.10 (1.21–3.65)**

15/20

2.54 (1.56–4.13)***

 Low

24/72

1.00 (Ref.)

21/54

1.56 (1.03–2.35)*

24/72

1.00 (Ref.)

9/26

1.42 (0.86–2.36)

12/12

1.68 (1.04–2.71)*

Test for interaction

χ2 = 11.80 (2 df); p < 0.01

χ2 = 12.42 (4 df); p = 0.01

  1. Abbreviation: CA/CN case numbers/control numbers; OR odds ratio; CI confidence interval; Ref. reference; df degree of freedom
  2. aData were matched by age and gender, calculated by backward stepwise log-linear regression, and adjusted for green tea consumption, fruits and vegetables intake, and exposure to cooking fumes
  3. *0.01 < p < 0.05, **0.001 < p < 0.01, ***p < 0.001