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Table 4 The joint effects of smoking status with DNMT3B − 149 genotypes and DNA damage level on lung cancer risk

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables Smoking status Pack-years of smoked
  Nonsmokers Current and ever smokers 0 1–39 ≥ 40
  CA/CN OR (95% CI)a CA/CN OR (95% CI)a CA/CN OR (95% CI)a CA/CN OR (95% CI)a CA/CN OR (95% CI)a
DNMT3B − 149 genotypes
 TT 83/242 1.09 (0.64–1.86) 100/103 2.83 (1.62–4.93)*** 83/242 1.09 (0.64–1.86) 37/52 2.39 (1.33–4.29)** 63/51 3.20 (1.80–5.67)***
 CT 5/20 1.00 (Ref.) 2/15 1.08 (0.43–2.75) 5/20 1.00 (Ref.) 0/6 2/9 1.46 (0.56–3.82)
Test for interaction χ2 = 3.64 (1 df); p = 0.06 χ2 = 5.43 (2 df); p = 0.07
DNA damage level
 High 49/100 1.21 (0.89–1.66) 57/29 3.97 (2.63–5.98)*** 49/100 1.21 (0.89–1.66) 19/17 3.03 (1.86–4.96)*** 38/28 4.90 (3.05–7.88)***
 Moderate 15/90 0.66 (0.45–0.98)* 24/35 2.37 (1.54–3.63)*** 15/90 0.66 (0.45–0.98)* 9/15 2.10 (1.21–3.65)** 15/20 2.54 (1.56–4.13)***
 Low 24/72 1.00 (Ref.) 21/54 1.56 (1.03–2.35)* 24/72 1.00 (Ref.) 9/26 1.42 (0.86–2.36) 12/12 1.68 (1.04–2.71)*
Test for interaction χ2 = 11.80 (2 df); p < 0.01 χ2 = 12.42 (4 df); p = 0.01
  1. Abbreviation: CA/CN case numbers/control numbers; OR odds ratio; CI confidence interval; Ref. reference; df degree of freedom
  2. aData were matched by age and gender, calculated by backward stepwise log-linear regression, and adjusted for green tea consumption, fruits and vegetables intake, and exposure to cooking fumes
  3. *0.01 < p < 0.05, **0.001 < p < 0.01, ***p < 0.001