Skip to main content

Table 2 The DNA tail moment per cell with stratification of specific characteristics in lung cancer cases and controls

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables Cases Controls
  N Mean (median) ± SD N Mean (median) ± SD
All 190 1.38 (1.17) ± 1.15 380 1.00 (0.98) ± 0.33b*
Gender
 Male 115 1.44 (1.18) ± 0.67 230 0.99 (0.96) ± 0.33
 Female 75 1.28 (1.14) ± 0.85 150 1.03 (0.99) ± 0.34
Age
  ≥ 60 132 1.38 (1.15) ± 1.27 252 1.02 (0.99) ± 0.33
 51–59 38 1.44 (1.27) ± 0.90 88 0.94 (0.96) ± 0.32
  ≤ 50 20 1.23 (1.15) ± 0.70 40 1.02 (0.99) ± 0.36
Smoking status
 Current or ever smokers 102 1.32 (1.15) ± 0.71 118 0.91 (0.89) ± 0.32c*
 Nonsmokers 88 1.44 (1.19) ± 1.51 262 1.04 (1.00) ± 0.33
Pack-years smoked
  ≥ 40 65 1.31 (1.19) ± 0.62 60 0.88 (0.90) ± 0.32c*
 1–39 37 1.34 (1.14) ± 0.85 58 0.94 (0.89) ± 0.32
 0 88 1.44 (1.19) ± 1.51 262 1.04 (1.00) ± 0.33
Green tea consumption (cup/day)
 0 146 1.29 (1.17) ± 0.74 250 1.02 (0.98) ± 0.34
  < 1 29 1.34 (1.15) ± 0.67 54 0.98 (0.97) ± 0.34
  ≥ 1 15 2.31 (1.32) ± 3.22 76 0.98 (0.98) ± 0.31
Green tea consumption (years)
 0 146 1.29 (1.17) ± 0.74 250 1.02 (0.98) ± 0.34
  ≤ 10 23 1.15 (1.14) ± 0.51 67 0.94 (0.96) ± 0.31
  > 10 21 2.24 (1.55) ± 2.73 63 1.02 (1.02) ± 0.32
Fruits and vegetables intake
  ≤ 14 48 1.50 (1.26) ± 0.83 139 0.95 (0.95) ± 0.35
 15–20 51 1.25 (1.21) ± 0.60 69 1.01 (0.95) ± 0.33
  ≥ 21 91 1.39 (1.09) ± 1.49 172 1.04 (1.01) ± 0.32
Exposure to cooking fumes (hours/week)
  ≥ 3 17 1.35 (1.14) ± 0.92 16 1.11 (1.10) ± 0.36
 1–3 19 1.14 (1.09) ± 0.57 15 0.96 (0.99) ± 0.26
  < 1 154 1.41 (1.18) ± 1.23 349 1.00 (0.97) ± 0.33
Family history of lung cancer
 Yes 15 1.12 (1.08) ± 0.67 6 0.98 (0.92) ± 0.16
 No 175 1.40 (1.18) ± 1.18 374 1.00 (0.98) ± 0.34
DNMT3B − 149 genotypes
 TT 183 1.32 (1.17) ± 0.75 345 1.00 (0.98) ± 0.33
 CT 7 2.99 (1.19) ± 4.63 35 1.03 (1.06) ± 0.33
Histological type
 Adenocarcinoma 108 1.42 (1.18) ± 1.39   
 Squamous cell carcinoma 51 1.39 (1.19) ± 0.75   
 Othersa 31 1.22 (0.97) ± 0.70   
  1. Abbreviation: N number; SD standard deviation
  2. aOthers included small cell carcinoma, large cell carcinoma, mixed cell carcinoma, and unspecific malignant cell
  3. bData was calculated by Mann-Whitney U test to examine the difference of DNA tail moment between the case and control groups
  4. cData were calculated by Mann-Whitney U test and Kruskal-Wallis test to examine the differences of DNA tail moment for each variable in controls
  5. *p < 0.001