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Table 2 The DNA tail moment per cell with stratification of specific characteristics in lung cancer cases and controls

From: Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

Variables

Cases

Controls

 

N

Mean (median) ± SD

N

Mean (median) ± SD

All

190

1.38 (1.17) ± 1.15

380

1.00 (0.98) ± 0.33b*

Gender

 Male

115

1.44 (1.18) ± 0.67

230

0.99 (0.96) ± 0.33

 Female

75

1.28 (1.14) ± 0.85

150

1.03 (0.99) ± 0.34

Age

  ≥ 60

132

1.38 (1.15) ± 1.27

252

1.02 (0.99) ± 0.33

 51–59

38

1.44 (1.27) ± 0.90

88

0.94 (0.96) ± 0.32

  ≤ 50

20

1.23 (1.15) ± 0.70

40

1.02 (0.99) ± 0.36

Smoking status

 Current or ever smokers

102

1.32 (1.15) ± 0.71

118

0.91 (0.89) ± 0.32c*

 Nonsmokers

88

1.44 (1.19) ± 1.51

262

1.04 (1.00) ± 0.33

Pack-years smoked

  ≥ 40

65

1.31 (1.19) ± 0.62

60

0.88 (0.90) ± 0.32c*

 1–39

37

1.34 (1.14) ± 0.85

58

0.94 (0.89) ± 0.32

 0

88

1.44 (1.19) ± 1.51

262

1.04 (1.00) ± 0.33

Green tea consumption (cup/day)

 0

146

1.29 (1.17) ± 0.74

250

1.02 (0.98) ± 0.34

  < 1

29

1.34 (1.15) ± 0.67

54

0.98 (0.97) ± 0.34

  ≥ 1

15

2.31 (1.32) ± 3.22

76

0.98 (0.98) ± 0.31

Green tea consumption (years)

 0

146

1.29 (1.17) ± 0.74

250

1.02 (0.98) ± 0.34

  ≤ 10

23

1.15 (1.14) ± 0.51

67

0.94 (0.96) ± 0.31

  > 10

21

2.24 (1.55) ± 2.73

63

1.02 (1.02) ± 0.32

Fruits and vegetables intake

  ≤ 14

48

1.50 (1.26) ± 0.83

139

0.95 (0.95) ± 0.35

 15–20

51

1.25 (1.21) ± 0.60

69

1.01 (0.95) ± 0.33

  ≥ 21

91

1.39 (1.09) ± 1.49

172

1.04 (1.01) ± 0.32

Exposure to cooking fumes (hours/week)

  ≥ 3

17

1.35 (1.14) ± 0.92

16

1.11 (1.10) ± 0.36

 1–3

19

1.14 (1.09) ± 0.57

15

0.96 (0.99) ± 0.26

  < 1

154

1.41 (1.18) ± 1.23

349

1.00 (0.97) ± 0.33

Family history of lung cancer

 Yes

15

1.12 (1.08) ± 0.67

6

0.98 (0.92) ± 0.16

 No

175

1.40 (1.18) ± 1.18

374

1.00 (0.98) ± 0.34

DNMT3B − 149 genotypes

 TT

183

1.32 (1.17) ± 0.75

345

1.00 (0.98) ± 0.33

 CT

7

2.99 (1.19) ± 4.63

35

1.03 (1.06) ± 0.33

Histological type

 Adenocarcinoma

108

1.42 (1.18) ± 1.39

  

 Squamous cell carcinoma

51

1.39 (1.19) ± 0.75

  

 Othersa

31

1.22 (0.97) ± 0.70

  
  1. Abbreviation: N number; SD standard deviation
  2. aOthers included small cell carcinoma, large cell carcinoma, mixed cell carcinoma, and unspecific malignant cell
  3. bData was calculated by Mann-Whitney U test to examine the difference of DNA tail moment between the case and control groups
  4. cData were calculated by Mann-Whitney U test and Kruskal-Wallis test to examine the differences of DNA tail moment for each variable in controls
  5. *p < 0.001
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BMC Cancer

ISSN: 1471-2407

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