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Fig. 1 | BMC Cancer

Fig. 1

From: Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas

Fig. 1

Examples of different histological types of HPV independent endocervical adenocarcinoma. (A-C) Minimal deviation adenocarcinoma (MDA): (A) Well-formed glands diffusely infiltrating cervical wall (H&E, 50 x). Neoplastic cells with clear and voluminous cytoplasm and basally located nuclei with mild cytologic atypia (H&E, 200 x). (C) Negative p16 expression in tumor cells. (D-F): Moderately differentiated gastric type adenocarcinoma: (D) Papillary proliferation of non-MDA gastric type adenocarcinoma (H&E, 50 x). (E) Neoplastic cells with moderate cytologic atypia and abundant clear cytoplasm showing distinct cell borders (H&E, 200 x). (F) Negative p16 expression in tumor cells. (G-I) Clear cell carcinoma: (G) Neoplastic glands infiltrating fibromatous stroma (H&E, 50 x). (H) Tumor cells with clear cytoplasm and severe nuclear atypia (H&E, 200 x). (I) Patch p16 expression in tumor cells

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