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Fig. 4 | BMC Cancer

Fig. 4

From: Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma

Fig. 4

Epigenetic regulation and post-translation modulation network of BTNL9 in LUAD. (A, B) Correlation between BTNL9 expression and methyltransferases (DNMTs) such as DNMT1, DNMT2, DNMT3A, and DNMT3B in LUAD and adjacent tissues using GEPIA. (C) Predicted miRNAs that bind to BTNL9 using miRMap, TargetScan, and miRWalk databases presented as a Venn diagram. (D) Overlapping 248 miRNAs verified using the StarBase database, hsa-miR-30b-3p, hsa-miR- 4709-3p, and hsa-miR-6514-3p were screened. (E) Predicted LncRNAs that bind to BTNL9 were predicted using the LncMap database. AP001462.6 was verified and screened using the LncACTdb2.0 database. (F, G) BTNL9 interacting proteins were identified using the STRING database and edited and visualized using Cytoscape software (V3.7.2). Hub genes were screened using the cytoHubba module in Cytoscape. (H, I) Ubibrowser database predicts that the substrate BTNL9 can be bound by E3 (MARCH8) ligases, with one potential E3 recognizing domain and two potential E3 identifying motifs

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