Table 4 Univariate and multivariate Cox proportional hazards regression models in patients with ESCC
Univariate analysis HR (95% CI) | P-value | Multivariate analysis HR (95% CI) | P-value | |
|---|---|---|---|---|
Age (years) | < 0.001 | < 0.001 | ||
< 60 years | 1.000 | – | 1.000 | |
≥ 60 years | 1.274 (1.112–1.461) | – | 1.341 (1.169–1.538) | |
Gender | 0.850 | – | ||
Male | 1.000 | – | – | |
Female | 0.987 (0.861–1.131) | – | – | |
Tumor location | 0.140 | – | ||
Upper/Middle | 1.000 | – | – | |
Lower | 1.117 (0.964–1.294) | – | – | |
Depth of invasion | < 0.001 | < 0.001 | ||
pT1 | 1.000 | – | 1.000 | – |
pT2 | 1.402 (1.051–1.869) | 0.022 | 1.085 (0.796–1.479) | 0.606 |
pT3 | 2.404 (1.845–3.133) | < 0.001 | 1.557 (1.137–2.131) | 0.006 |
pT4 | 3.437 (2.168–4.451) | < 0.001 | 2.721 (1.527–4.848) | 0.001 |
Lymph node metastasis | < 0.001 | 0.016 | ||
pN0 | 1.000 | – | 1.000 | – |
pN1 | 1.725 (1.493–1.994) | < 0.001 | 1.354 (1.066–1.718) | 0.013 |
pN2 | 2.241 (1.881–2.670) | < 0.001 | 1.530 (1.142–2.048) | 0.004 |
Stage | < 0.001 | 0.036 | ||
I | 1.000 | – | 1.000 | – |
II | 1.973 (1.456–2.674) | < 0.001 | 1.432 (1.007–2.035) | 0.046 |
III | 3.657 (2.712–4.933) | < 0.001 | 1.705 (1.078–2.696) | 0.023 |
Differentiation | 0.122 | 0.046 | ||
G1 | 1.000 | – | – | |
G2 | 1.411 (1.105–1.961) | 0.040 | – | – |
G3 | 1.374 (0.984–1.918) | 0.062 | – | – |
NLR | < 0.001 | < 0.001 | ||
< 3.29 | 1.000 | 1.000 | – | |
≥ 3.29 | 1.859 (1.678–2.060) | 1.578 (1.373–1.814) | – | |
NMR | 0.202 | – | ||
< 12.77 | 1.000 | – | ||
≥ 12.77 | 2.010 (1.716–2.355) | – | – | |
LMR | < 0.001 | 0.001 | ||
≥ 2.95 | 1.000 | – | 1.000 | – |
< 2.95 | 1.373 (1.205–1.566) | – | 1.265 (1.107–1.445) | |
RDW | 0.049 | 0.366 | ||
< 15.05% | 1.000 | 1.000 | – | |
≥ 15.05% | 1.1411.001–1.301) | 1.063 (0.931–1.213) | – | |
PDW | 0.016 | 0.104 | ||
< 13.65% | 1.000 | – | 1.000 | – |
≥ 13.65% | 1.280 (1.048–1.562) | – | 1.181 (0.966–1.444) | – |