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Table 4 Transcription factors of the differentially expressed MMPs

From: MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma

Key TF Description P value FDR Regulated genes
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 4.20E-09 7.55E-08 MMP9, MMP14, MMP1
ETV4 ets variant 4 1.15E-07 1.03E-06 MMP14, MMP1, MMP2
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.72E-07 1.03E-06 MMP14, MMP2, MMP9
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 3.69E-07 1.35E-06 MMP1, MMP9, MMP2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 3.76E-07 1.35E-06 MMP9, MMP2, MMP1, MMP14
KLF8 Kruppel-like factor 8 5.65E-06 1.70E-05 MMP14, MMP9
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 7.50E-06 1.73E-05 MMP9, MMP2, MMP14, MMP1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 7.70E-06 1.73E-05 MMP1, MMP2, MMP9, MMP14
SNAI2 snail homolog 2 (Drosophila) 1.83E-05 3.67E-05 MMP17, MMP9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.44E-05 6.20E-05 MMP1, MMP9
JUN jun proto-oncogene 3.91E-05 6.40E-05 MMP9, MMP2, MMP1
SP1 Sp1 transcription factor 4.40E-05 6.61E-05 MMP2, MMP9, MMP11, MMP14
TWIST1 twist basic helix-loop-helix transcription factor 1 0.000119 0.000165 MMP2, MMP1
FOS FBJ murine osteosarcoma viral oncogene homolog 0.000318 0.000409 MMP9, MMP1
PPARG peroxisome proliferator-activated receptor gamma 0.000427 0.000512 MMP9, MMP1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.000494 0.000556 MMP2, MMP9
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.000611 0.000647 MMP1, MMP9
TP53 tumor protein p53 0.0026 0.0026 MMP1, MMP2