Table 2 The GO function enrichment analysis of MMP family members and neighboring genes (Metascape)
From: MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma
GO | Category | Description | Count | % | Log10(P) | Log10(q) |
|---|---|---|---|---|---|---|
GO:0004222 | GO Molecular Functions | metalloendopeptidase activity | 29 | 39.73 | −51.76 | −47.41 |
GO:0062023 | GO Cellular Components | collagen-containing extracellular matrix | 17 | 23.29 | −15.20 | −11.96 |
GO:0008236 | GO Molecular Functions | serine-type peptidase activity | 11 | 15.07 | −11.66 | −8.46 |
GO:0035987 | GO Biological Processes | endodermal cell differentiation | 7 | 9.59 | −10.68 | −7.54 |
GO:0070820 | GO Cellular Components | tertiary granule | 9 | 12.33 | −9.36 | −6.33 |
GO:0030246 | GO Molecular Functions | carbohydrate binding | 10 | 13.70 | −8.74 | −5.77 |
GO:0051045 | GO Biological Processes | negative regulation of membrane protein ectodomain proteolysis | 4 | 5.48 | −8.54 | −5.59 |
GO:0005518 | GO Molecular Functions | collagen binding | 6 | 8.22 | −7.62 | −4.78 |
GO:0009611 | GO Biological Processes | response to wounding | 13 | 17.81 | −7.55 | −4.73 |
GO:0070006 | GO Molecular Functions | metalloaminopeptidase activity | 4 | 5.48 | −6.16 | −3.57 |
GO:0005509 | GO Molecular Functions | calcium ion binding | 10 | 13.70 | −4.82 | −2.42 |
GO:1901681 | GO Molecular Functions | sulfur compound binding | 6 | 8.22 | −4.22 | −1.89 |
GO:0072562 | GO Cellular Components | blood microparticle | 4 | 5.48 | −3.24 | −1.00 |
GO:0042698 | GO Biological Processes | ovulation cycle | 3 | 4.11 | −3.23 | −1.00 |
GO:0031348 | GO Biological Processes | negative regulation of defense response | 5 | 6.85 | −3.22 | −0.99 |
GO:0005788 | GO Cellular Components | endoplasmic reticulum lumen | 5 | 6.85 | −2.92 | −0.72 |
GO:0051591 | GO Biological Processes | response to cAMP | 3 | 4.11 | −2.72 | −0.56 |
GO:0005125 | GO Molecular Functions | cytokine activity | 4 | 5.48 | −2.48 | −0.34 |
GO:0043900 | GO Biological Processes | regulation of multi-organism process | 5 | 6.85 | −2.25 | −0.12 |
GO:0019838 | GO Molecular Functions | growth factor binding | 3 | 4.11 | −2.25 | −0.12 |