Prospective pharmacological methodology for establishing and evaluating anti-cancer drug resistant cell lines

BMC Cancer

Table 2 Simple linear regression analysis of resistance indicator candidates using sunitinib-treated SNU-267 cells

		Equation	95% confidence interval of slope	p value
Growth rate	Control	y = 0.04181x + 244.4	−0.1577 to 0.2414	0.6668
Growth rate	Resistant cells	y = 0.4506x + 107.4	0.2190 to 0.6821	0.0007
IC₅₀	Control	y = 0.0006978x + 5.224	−0.001398 to 0.002793	0.4847
IC₅₀	Resistant cells	y = 0.0003528x + 6.639	−0.002357 to 0.003063	0.7798
GI₅₀	Control	y = 0.0004711x + 4.34	−0.001095 to 0.002037	0.5293
GI₅₀	Resistant cells	y = 0.001636x + 4.439	−0.0005583 to 0.00383	0.1303
GI₁₀₀	Control	y = − 0.0001539x + 6.351	−0.00131 to 0.001002	0.7805
GI₁₀₀	Resistant cells	y = 0.007164x + 4.328	0.004733 to 0.009596	< 0.0001
GR₅₀	Control	y = 0.000252x + 4.646	−0.0008375 to 0.001342	0.6275
GR₅₀	Resistant cells	y = 0.002473x + 4.427	0.0004343 to 0.004512	0.0215
GR₁₀₀	Control	y = − 0.0003388x + 6.453	−0.001525 to 0.000847	0.5516
GR₁₀₀	Resistant cells	y = 0.007258x + 4.248	0.004843 to 0.009674	< 0.0001

ISSN: 1471-2407