Fig. 3

Schematic representation of the sunitinib-resistant cell line establishment process. The schema timeline is from the day on which the cells were exposed to sunitinib up to 1000 days later. SNU-228 cells (A) were eventually exposed to sunitinib for 831 days and SNU-267 cells (B) for 957 days. Closed arrows highlight exposure to the drugs, and open arrows indicate when sunitinib resistance was measured