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Table 4 Associations between body composition measures and breast cancer subtype

From: Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study

Model 3

Luminal A

aOR (95% CI)

Luminal B

aOR (95% CI)

Triple Negative

aOR (95% CI)

HER2

aOR (95% CI)

BMI (kg/m2) quartile

 ≤ 22.5

Ref

Ref

Ref

Ref

 22.5–25.5

0.55 (0.22, 1.41)

0.94 (0.36, 2.50)

0.41 (0.16, 1.06)

0.97 (0.34, 2.76)

 25.6–29.8

0.33 (0.12, 0.90)

0.63 (0.22, 1.76)

0.47 (0.19, 1.14)

0.70 (0.24, 2.07)

 > 29.8

0.51 (0.21, 1.24)

0.35 (0.11, 1.13)

0.48 (0.20, 1.13)

0.68 (0.23, 1.97)

  P-trend

0.10

0.06

0.13

.38

aOR (95% CI) per unit SD

0.82 (0.59, 1.16)

0.63 (0.42, 0.95)

0.81 (0.58, 1.12)

0.74 (0.50, 1.09)

 Pre/peri-menopausal

0.59 (0.35, 0.99)

0.48 (0.26, 0.90)

0.89 (0.56, 1.42)

0.49 (0.27, 0.90)

 Post-menopausal

1.03 (0.64, 1.68)

0.66 (0.36, 1.21)

0.55 (0.32, 0.95)

1.10 (0.61, 1.98)

Height (cm) quartile (all)

 ≤ 156.0

Ref

Ref

Ref

Ref

 > 156.0 - ≤160.0

0.88 (0.29, 2.68)

0.76 (0.24, 2.41)

1.33 (0.53, 3.36)

0.83 (0.31, 2.22)

 > 160.0 - ≤164.0

1.42 (0.58, 3.50)

0.80 (0.29, 2.18)

1.02 (0.43, 2.41)

0.66 (0.27, 1.65)

 > 164.0

1.39 (0.55, 3.51)

1.18 (0.46, 3.03)

1.01 (0.41, 2.45)

0.22 (0.06, 0.83)

  P-trend

.35

.74

.89

.03

aOR (95% CI) per unit SD

1.20 (0.86, 1.67)

1.09 (0.76, 1.57)

1.05 (0.77, 1.44)

0.74 (0.51, 1.07)

 Pre/peri-menopausal

1.23 (0.78, 1.93)

1.39 (0.85, 2.27)

0.77 (0.48, 1.23)

0.72 (0.44, 1.16)

 Post-menopausal

1.19 (0.71, 2.01)

0.78 (0.46, 1.33)

1.43 (0.89, 2.28)

0.78 (0.42, 1.44)

Weight (kg) quartile (all)

 ≤ 56.7

Ref

Ref

Ref

Ref

 > 56.7 - ≤65.0

0.46 (0.16, 1.29)

2.14 (0.76, 6.03)

0.52 (0.21, 1.30)

0.84 (0.32, 2.22)

 > 65.0 - ≤77.0

0.65 (0.25, 1.73)

1.32 (0.42, 4.18)

0.77 (0.32, 1.88)

0.48 (0.15, 1.54)

 > 77.0

0.73 (0.30, 1.75)

0.46 (0.12, 1.77)

0.54 (0.23, 1.30)

0.52 (0.19, 1.44)

  P-trend

.67

.14

.29

.15

aOR (95% CI) per unit SD

0.91 (0.65, 1.27)

0.68 (0.45, 1.01)

0.83 (0.60, 1.14)

0.68 (0.46, 1.01)

 Pre/peri-menopausal

0.70 (0.43, 1.16)

0.59 (0.33, 1.06)

0.81 (0.50, 1.30)

0.45 (0.24, 0.84)

 Post-menopausal

1.10 (0.67, 1.78)

0.62 (0.34, 1.15)

0.68 (0.41, 1.13)

0.99 (0.55, 1.78)

  1. Multinomial logistic regression models predicting odds of breast cancer subtype versus controls. Adjusted for reproductive and clinical characteristics: age, age at menarche, number of pregnancies, number of births, menopausal status (not included in stratified models), and prior hypertension diagnosis
  2. P-trend based on continuous predictors
  3. aOR per unit SD was modeled as a one-unit increase in standard deviation of the body composition variable from its mean-centered value. These models were stratified by menopausal status
  4. Bolded values indicate significance at p < .05
  5. Abbreviations: aOR adjusted odds ratio, CI confidence interval, SD standard deviation
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BMC Cancer

ISSN: 1471-2407

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