Fig. 2
From: EMMPRIN expression is associated with metastatic progression in osteosarcoma
Reversal of MMP2 stimulation in co-cultures of SaOS-2 and osteoblast by EMMPRIN siRNA transfection. a SaOS-2 and osteoblast showed weak gelatinolytic band for pro-MMP2 when cultured alone (Lanes 1, 2). When osteoblast and SaOS-2 were co-cultured, enhanced stimulation of pro-MMP2 was observed (Lane 3). This stimulation was reversed by transfection of SaOS-2 with EMMPRIN-targeting siRNA (Lanes 4–6). Data shown are representative images of individual cell lines from three separate experiments. b Comparison of grayscale ratio of gelatinolytic band for pro-MMP2 *, p < 0.05 compared with control