Table 2 Statistical differences among four periods in each item of PHQ-9 and GAD-7

Q1. Little interest or pleasure in doing things?

0.75 ± 0.96

0.84 ± 0.78

0.88 ± 0.94

0.57 ± 0.49

0.739

Q2. Feeling down, depressed, or hopeless?

0.79 ± 0.87

0.75 ± 0.77

0.84 ± 0.85

0.71 ± 0.70

0.961

Q3. Trouble falling or staying asleep or sleeping too much?

0.96 ± 1.00

0.94 ± 0.92

1.03 ± 1.09

1.00 ± 1.07

0.971

Q4. Feeling tired or having little energy?

1.08 ± 1.02

0.94 ± 0.86

1.22 ± 0.87

0.86 ± 0.99

0.546

Q5. Poor appetite or overeating?

0.81 ± 0.95

0.78 ± 0.87

0.69 ± 0.82

0.71 ± 0.88

0.957

Q6. Feeling bad about yourself or that you are a failure or have let yourself or your family down?

0.39 ± 0.07

0.38 ± 0.67

0.53 ± 0.76

0.43 ± 1.05

0.638

Q7. Trouble concentrating on things, such as reading the newspaper or watching television?

0.66 ± 0.40

0.46 ± 0.65

0.69 ± 0.93

0.14 ± 0.35

0.060

Q8. Moving or speaking so slowly that other people could have noticed? Or so fidgety or restless that you have been moving a lot more than usual?

0.38 ± 0.74

0.41 ± 0.69

0.56 ± 0.84

0.71 ± 1.03

0.246

Q9. Thoughts that you would be better off dead or thoughts of hurting yourself in some way?

0.31 ± 0.63

0.32 ± 0.65

0.16 ± 0.45

0.29 ± 0.70

0.664

Q1. Feeling nervous, anxious, or on edge

0.75 ± 0.76

0.68 ± 0.68

0.78 ± 0.79

0.57 ± 1.05

0.833

Q2. unable to stop or control worrying

0.53 ± 0.75

0.58 ± 0.74

0.78 ± 0.83

0.71 ± 1.03

0.405

Q3. Worrying too much about different things

0.91 ± 0.84

0.93 ± 0.81

1.16 ± 0.95

0.86 ± 0.99

0.502

Q4. Trouble relaxing

0.63 ± 0.84

0.55 ± 0.80

0.78 ± 0.87

0.43 ± 0.73

0.559

Q5. Being so restless that it is hard to sit still

0.41 ± 0.76

0.38 ± 0.60

0.41 ± 0.56

0.43 ± 0.73

0.990

Q6. Becoming easily annoyed or irritable

0.55 ± 0.80

0.65 ± 0.84

0.69 ± 0.78

0.43 ± 1.05

0.686

Q7. Feeling afraid as if something awful might happen

0.50 ± 0.75

0.51 ± 0.68

0.50 ± 0.72

0.43 ± 0.73

0.995