Fig. 8

GSA analysis. Statistically significant PRCC values (p-value< 0.05) for tumor cells, NK cells, CTLs, MDSCs, T helper cells, Tregs, IL-2, IFN-γ, and TGF-β at days 20 (A. A), 50 (A. B) and 100 (A. C) after tumor injection. The mean of PRCC values for five replications of PRCC analysis was depicted in each pixel. Black pixels (‘NaN’) show ‘not a number’ and represent no significant correlation between outcome measures (population/concentration of cells/cytokines, elements in the vertical axis) and kinetic parameters of the model (elements in the horizontal axis). The standard deviation of significant PRCC values (p-value< 0.05) for five replications of PRCC analysis for tumor cells, NK cells, CTLs, MDSCs, T helper cells, Tregs, IL-2, IFN-γ and TGF-β at days 20 (B. A), 50 (B. B) and 100 (B. C) after tumor injection. The standard deviation of significant PRCC values for five replications of PRCC analysis was depicted in each pixel. P-values of PRCC analysis for tumor cells, NK cells, CTLs, MDSCs, T helper cells, Tregs, IL-2, IFN-γ, and TGF-β at days 20 (C. A), 50 (C. B), and 100 (C. C) after tumor injection. The maximum of p-values for five replications of PRCC analysis was depicted in each pixel. (D) The absolute mean value and standard deviation of the elementary effects test. Figures 8. D presents the relative importance of kinetic parameters of the TIS model, considering the population/concentration of cells/ cytokines at day 100 as the read-out, including the population of tumor cells (D. A), NK cells (D. B), CTLs (D. C), MDSCs (D. D), T helper cells (D. E), Tregs (D. F), IL-2 (D. G), IFN-γ (D. H) and TGF-β (D. K). Each kinetic parameter is specified by two Morris indices, μ *(horizontal axis) and σ (vertical axis), which describe the significance of the effects and the interaction effects, respectively