Fig. 6

Dynamics of all cells/cytokines in strategies: control, 5-FU, Anti-CD25, and combination therapy with an optimized treatment schedule and comparison treatment efficacies and analysis of interactions among treatments. The blue lines in Fig. 6. B, D, and F show predicted dynamics of cells/cytokines in the control group, and the red lines show with 5-FU treatment (on specified time points), the yellow lines show with anti-CD25 therapy (on specified time points) and purple lines depict the dynamics under combinatorial manner. In each subplot in Fig. 6. B, D, and F (except for the second and third figures in the last panel), the y-axis represents the number/concentration of cell population/cytokine, and the x-axis represents the time in days after tumor inoculation. The initial condition is the same as those given in Fig. 3. The second and third figures in the fourth panels of fig. 6. B, D, and F show the terms related to 5-FU and anti-CD25 therapies, respectively. The overall efficacy of 5-FU treatment, anti-CD25 treatment, and combination therapy was plotted as the percentage of tumor growth inhibition using instantaneous tumor size (first panel of figs. 6. A, C, and E) and average tumor size (second panel of figs. 6. A, C and E) as outcomes. The blue line represents the inhibition percentage of tumor growth under 5-FU treatment on specified time points after tumor injection calculated based on the instantaneous tumor size during time and the red line under anti-CD25 treatment on specified time points after tumor inoculation and the yellow line under combination therapy. (Third panel of fig. 6. A, C and E) The Bliss combination index (CI) for 5-FU and Anti- treatments combination using instantaneous tumor size (CI inst) and average tumor size (CI ave) as an outcome