Fig. 3
Dynamics of all species in strategies: control, 5-FU, Anti-CD25, and combination therapy. The blue dashed lines show predicted dynamics of cells/cytokines in the control group, and the red lines show with 5-FU treatment (on days 1, 2, 3, and 4 after tumor inoculation), the yellow lines show with anti-CD25 therapy (on days 3, 6, 10, 13, 17 and 20 after tumor inoculation) and purple lines depict the dynamics of cells/cytokines under combination therapy. In each subplot (except for the second and third figures in the last panel), the y-axis represents the number/concentration of cell population/cytokine, and the x-axis represents the time in days after tumor inoculation. The initial population/concentration of tumor cells, NKs, CTLs, MDSCs, TCD4+, Treg, IL-2, IFN-γ, and TGF-β have all been set to 6 × 105, 105840, 21 × 104, 3 × 103, 564480, 42336, 2.5107 × 10−6, 3.9348 × 10−7, 5.363 × 10−7, respectively. The second and third figures in the fourth panel are parameters and terms related to 5-FU and anti-CD25 therapies, respectively