Fig. 2

Data fitting. The blue line shows predicted Panc02 tumor volume dynamics in no treatment case and blue stars are records of Panc02 tumor volume on days 5, 10, 15, 20, and 25 in the control group (Panc02 tumor inoculation is carried out on day 0 and normalized root mean square error (NRMSE = 0.1107) is used as a measure of goodness of fit). The purple dashed line shows predicted dynamics of Panc02 tumor volume and purple ‘>‘are data points gathered from experimental data in the 5-FU treatment group (5-FU therapy is carried out on days 1, 2, 3, and 4 after Panc02 tumor injection on day 0, and data record is carried out on days 5, 10, 15, 20 and 25, and NRMSE of 0.1085 is computed to assess model fitting). The black dotted line shows predicted dynamics of Panc02 tumor cells and black ‘circles’ are data points gathered from in vivo experiments in the anti-CD25 treatment group (anti-CD25 therapy is carried out on days 3, 6, 10, 13, 17, and 20 after tumor inoculation on day 0 and data record is carried out on days 7, 14, 21, 28 and 35, and NRMSE of 0.0928 is computed to assess model fitting)