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Table 4 Medical history associated with different esophageal lesions

From: Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study

Medical history

HGIN/ESCC

LGIN

Esophagitis

OR

(95% CI)

P value

Adjusted OR a

(95% CI)

P value

OR

(95% CI)

P value

Adjusted OR a

(95% CI)

P value

OR

(95% CI)

P value

Adjusted OR a

(95% CI)

P value

Take an acid suppressant

0.65 (0.39–1.02)

0.077

0.68 (0.41–1.07)

0.119

0.49 (0.37–0.63)

< 0.001

0.51 (0.39–0.66)

< 0.001

0.68 (0.59–0.79)

< 0.001

0.70 (0.60–0.80)

< 0.001

Take antibiotics

Not take

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

 Not every week

0.27 (0.07–1.08)

0.063

0.34 (0.08–1.36)

0.127

0.76 (0.12–0.72)

0.180

0.90 (0.59–1.36)

0.617

0.54 (0.40–0.73)

< 0.001

0.61 (0.45–0.83)

0.001

 Not every day

0.68 (0.17–2.74)

0.588

0.81 (0.20–3.28)

0.764

0.80 (0.43–1.51)

0.492

0.93 (0.49–1.77)

0.826

0.70 (0.461.08)

0.107

0.75 (0.49–1.16)

0.197

 Every day

0.25 (0.04–1.80)

0.169

0.28 (0.04–1.99)

0.202

0.30 (0.12–0.72)

0.007

0.33 (0.14–0.80)

0.014

0.39 (0.24–0.63)

< 0.001

0.40 (0.24–0.65)

< 0.001

Number of teeth lost

 None

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

1.00 (reference)

–

 1–3

1.07 (0.84–1.36)

0.570

0.86 (0.68–1.09)

0.210

1.38 (1.24–1.54)

< 0.001

1.17 (1.04–1.31)

0.007

1.24 (1.16–1.33)

< 0.001

1.14 (1.06–1.23)

< 0.001

 4–6

1.68 (1.26–2.22)

< 0.001

1.11 (0.83–1.48)

0.484

1.53 (1.31–1.77)

< 0.001

1.12 (0.96–1.30)

0.137

1.35 (1.22–1.48)

< 0.001

1.15 (1.04–1.27)

0.005

 7–11

1.54 (1.01–2.26)

0.035

0.83 (0.55–1.25)

0.382

1.88 (1.55–2.26)

< 0.001

1.19 (0.98–1.44)

0.077

1.61 (1.41–1.82)

< 0.001

1.27 (1.12–1.45)

< 0.001

 12–31

2.62 (1.70–3.87)

< 0.001

1.21 (0.79–1.84)

0.385

2.18 (1.73–2.72)

< 0.001

1.26 (0.99–1.58)

0.054

2.05 (1.76–2.37)

< 0.001

1.54 (1.32–1.79)

< 0.001

 Complete denture

2.72 (1.72–4.10)

< 0.001

1.20 (0.77–1.87)

0.420

2.55 (2.02–3.19)

< 0.001

1.42 (1.11–1.78)

0.004

2.66 (2.30–3.07)

< 0.001

1.94 (1.66–2.25)

< 0.001

Loose teeth

1.89 (1.27–2.70)

0.001

1.48 (0.99–2.12)

0.042

1.49 (1.21–1.82)

< 0.001

1.23 (1.00–1.51)

0.049

1.23 (1.06–1.42)

0.005

1.10 (0.95–1.27)

0.202

  1. Source: WHO tumor histological classification 2000
  2. BMI body mass index (kg/m2), LGIN low-grade intraepithelial neoplasia, HGIN high-grade intraepithelial neoplasia, ESCC esophageal squamous cell carcinoma
  3. aadjusted for age, gender, education, BMI and income